Circulating concentrations of leptin and IGF-I, leptin gene expression, and serum binding of [126I]ovine leptin in cattle during pubertal development, as well as leptin gene expression and circulating concentrations of leptin during the estrous cycle and different calendar seasons, were investigated. Multivariate regression analysis was utilized to evaluate temporal changes in BW, leptin mRNA, ...

Leptin is a hormone secreted by white fat tissue and signals the amount of overall body fat to the hypothalamus. The circulating concentration of leptin correlates with the level of obesity. Breast cancer risk is higher in obese postmenopausal women compared with postmenopausal women of a normal weight, and high leptin concentrations may contribute to this risk. In the present study, SK-BR-3 an...

BACKGROUND Leptin, a hormone produced primarily by adipose tissue, is known to be present in serum as both monomeric (free) and higher molecular mass (bound) forms, but little is known about the nature of the bound forms or physiological variation in binding capacity. METHODS A new method to quantify the free and bound forms was developed, based on HPLC separation and RIA quantification in ch...

Leptin concentrations in the interscapular brown adipose tissue (IBAT) of the common shrew (Sorex araneus) were measured in different seasons. The leptin concentrations in IBAT were much higher than in the liver, where leptin is supposed to be of blood origin. In the heart muscle no detectable amount of leptin was found. There were clear seasonal variations in the leptin concentrations in IBAT....

The Ob protein leptin has been shown to be closely correlated with measures of body fat in humans and animals. Studies have suggested that there are both gender and ethnic differences in serum leptin concentrations, even after controlling for total and relative body fat and body mass index. We hypothesized that gender and ethnic differences in serum leptin concentrations are due to differences ...

Carlson, G. L., M. Saeed, R. A. Little, and M. H. Irving. Serum leptin concentrations and their relation to metabolic abnormalities in human sepsis. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E658–E662, 1999.—Circulating leptin concentrations are raised in animal models of inflammation and sepsis. The purpose of this study was to determine the effect of sepsis on serum leptin concentration in...

The objective of this study was to evaluate the relationship between serum concentrations of the hormone leptin with growth and carcass traits insix distinct breeds of pigs entered into the 2000 National Barrow Show Sire Progeny Test. Breeds evaluated were Berkshire (n = 131), Chester White (n = 33), Duroc (n = 40), Landrace (n = 23), Poland China (n = 26), and Yorkshire (n = 41). Serum samples...

Objective(s) The aim of this study was to investigate the effects of aerobics, pilates exercises and low calorie diet on leptin levels and some lipid profiles and anthropometric factors in sedentary women. Materials and Methods Forty six women (age 36.41±3.47) were recruited and divided into four groups: aerobic exercise group (EX), Pilates exercise group (Pilates), low calorie diet (LCD) an...

OBJECTIVE To determine effects of obesity and diet in dogs on plasma lipid and lipoprotein concentrations by assaying plasma leptin and ghrelin concentrations and determining total plasma cholesterol and triglyceride concentrations as well as the concentrations of cholesterol and triglycerides in various lipoprotein classes (ie, very-low-density, low-density, and high-density lipoproteins). A...

OBJECTIVE Leptin, neuropeptide-Y (NPY) and orexin are peptides regulating energy metabolism and appetite control. NPY and orexin are mainly found in the central nervous system and they have also recently been found in the peripheral nervous system. We investigated how fasting affects changes in circulating concentrations of these peptides and their association with nutritional and metabolic par...