Drug therapy is a complex and important process and because of the importance of drug interactions, especially in in-patients, accompanying problems and obstacles would exist as a result of concomitant use of drugs in these patients. For this purpose 3130 prescription order forms from Bou-Ali hospital were collected and all potential drug interactions presentwere extracted and evaluated in term...

INTRODUCTION The aim of this study was to determine the prevalence and characteristics of benzodiazepine (BZD) abuse among intravenous opioid users in Singapore. MATERIALS AND METHODS Eligibility criteria for inclusion in this study were all intravenous buprenorphine abusers, who presented to the Community Addictions Management Programme (CAMP) over a 1-year period from February 2005 to Janua...

OBJECTIVES We quantified concomitant medication polypharmacy, pharmacokinetic and pharmacodynamic interactions, adverse effects and adherence in Australian adults on effective antiretroviral therapy. DESIGN Cross-sectional. METHODS Patients recruited into a nationwide cohort and assessed for prevalence and type of concomitant medication (including polypharmacy, defined as ≥5 concomitant med...

Concomitant use of several drugs by ICU( Intensive Care Unit) patients is often unavoidable. In these patients, pharmacokinetic drug interactions are very likely. The current study was designed to evaluate these interactions in patients hospitalized in an ICU of a teaching hospital in Tehran, Iran. A questionnaire was designed and used to collect study data. The study was done in the ICU of a t...

Drug therapy is a complex and important process and because of the importance of drug interactions, especially in in-patients, accompanying problems and obstacles would exist as a result of concomitant use of drugs in these patients. For this purpose 3130 prescription order forms from Bou-Ali hospital were collected and all potential drug interactions presentwere extracted and evaluated in term...

Concomitant use of several drugs by ICU( Intensive Care Unit) patients is often unavoidable. In these patients, pharmacokinetic drug interactions are very likely. The current study was designed to evaluate these interactions in patients hospitalized in an ICU of a teaching hospital in Tehran, Iran. A questionnaire was designed and used to collect study data. The study was done in the ICU of a t...

We sought to assess whether a high-profile publication that demonstrated serious clinical consequences of specific drug-drug interactions (DDIs) reduced the concomitant use of those drugs. We conducted a quasi-experimental study using 2000-2008 prescription claims from a commercial health insurer to examine trends in the dispensing of the interacting drug pairs (angiotensin-converting enzyme in...

Background: Prostate cancer is known as one of the most prevalent health disorders in the male population globally. The aim of the current study was to evaluate the effects of separate and concomitant use of MK-2206 and salinomycin on prostate cancer cell line.  Methods: The antitumor potential of separate and concomitant use of MK-2206 and salinomycin was evaluated in a panel of prostate ca...

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to evaluate off-label and off-nccn guidelines uses of antineoplastic drugs in a major chinese hospital.totally 1122 patients were selected from july to december 2011. then, the off-label and off-nccn guidelines uses of antineoplastic drugs were analyzed.in 798 of 1122 patients (71.12%), drugs were used for off-label. in 317 of 1122 patients (28.25%), the drugs were prescribed for off-label and ...