behcet’s disease is a rare immune mediated systemic vasculitis which besides it’s more frequent involvement of eyes and skin,   sometimes present with aortic pseudo aneurysm and more rarely cardiac inflammatory masses.a 51-year-old patient with behçet’s disease presented with two symptomatic aortic pseudoaneurysms concomitant with a right atrial mass. computed tomography (ct) revealed one supra...

Psoriasis is a chronic inflammatory disease which is a result of complex interactions between genetic, environmental, and immunological factors. Psoriasis is now accepted as a systemic disorder accompanied by comorbidities rather than simply a cutaneous disease. Psoriasis has been associated with a number of systemic diseases such as diabetes mellitus, obesity, hypertension, metabolic syndrome,...

Psoriasis and pemphigus vulgaris are two inflammatory and autoimmune diseases. Their concomitant occurrence in one patient is very rare. We describe a 57-year-old patient with a history of severe plaque type psoriasis for 2 years. After a few months, he presented with disseminated bullae and mucosal erosions which were documented as pemphigus vulgaris. Both of the diseases were successfully con...

Systemic autoinflammatory diseases encompass different rare clinical entities characterized by recurrent acute inflammatory episodes secondary to a dysregulated inflammatory process. Since their first clinical descriptions, the Mendelian hereditary nature of some of them became evident, with their genetic and molecular basis being recently elucidated. There are disease-causing mutations in gene...

1Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China 2Laboratory of Autoimmunity, School of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968, USA 3Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-7660, USA 4Department of Rheumatology, Peking Un...

Acne is a very common, multifactorial, complex, and chronic disease of the pilosebaceous unit that affects approximately 85% of adolescent patients and 3% of adult patients. The roles of sebaceous glands, androgens, follicular epithelial cells, Propionibacterium acnes, immune mediators, environmental factors, and genetic factors are well known in acne pathogenesis. Although it is not a life-thr...

Current evidence suggests that periodontal disease may be associated with systemic diseases. This paper reviewed the published data about the relationship between periodontal disease and cardiovascular diseases, adverse pregnancy outcomes, diabetes and respiratory diseases, focusing on studies conducted in the Brazilian population. Only a few studies were found in the literature focusing on Bra...