A 48-year-old fisherman from Amazonas (north of Brazil) developed a small papule on the anterior left leg after a traumatic injury with a piece of wood 20 years ago. Over the course of years, multiple large, confluent, reddish to brownish nodules with eventual ulceration came into being on the left leg and extended to the left thigh. There was a solitary, domed-shaped nodule on the right arm (F...

The most physiological type of cell cycle arrest - namely, contact inhibition in dense culture - is the least densely studied. Despite cell cycle arrest, confluent cells do not become senescent. We recently described that mTOR (target of rapamycin) is inactive in contact-inhibited cells. Therefore, conversion from reversible arrest to senescence (geroconversion) is suppressed. I this Perspectiv...

We show that a transitively reduced digraph has a confluent upward drawing if and only if its reachability relation has order dimension at most two. In this case, we construct a confluent upward drawing with O(n2) features, in an O(n)×O(n) grid in O(n2) time. For the digraphs representing series-parallel partial orders we show how to construct a drawing with O(n) features in an O(n)×O(n) grid i...

We address the problem of specifying concurrent processes that can make local nondeterministic decisions without affecting global system behavior—the sequence of events communicated along each inter-process communication channel. Such nondeterminism can be used to cope with unpredictable execution rates and communication delays. Our model resembles Kahn’s, but does not include unbounded buffere...

Chronic excess ingestion of nonsteroid anti-inflammatory drugs causes renal medullary necrosis. Previously, using an immortalized line of mouse inner medullary collecting ducts cells (mIMCD3), we found that acetaminophen, salicylic acid, and caffeine are toxic, and the effects of acetaminophen and caffeine are strongly additive. Furthermore, toxicity was greater in proliferating than in nonprol...