The pulsed electron avalanche knife (PEAK-fc, Carl Zeiss Meditec) is an electrosurgical cutting device that allows precise "cold" and traction-free tissue dissection. We describe its applicability and safety for anterior capsulotomy in a child with congenital cataract and an adult patient with mature cataract. The PEAK-fc was set at a voltage of 600 V and a pulse repetition rate of 80 Hz. Anter...

PURPOSE To investigate the activation of three unfolded protein response (UPR) pathways in the lenses of age-related, high myopia-related and congenital cataracts. METHODS AND MATERIALS Lens specimens were collected from patients during small incision cataract surgery. Lenses from young cadaver eyes were collected as normal controls. Real-time PCR and Western blotting were performed to detect...

purpose : we describe our experience on safety and effectiveness of phacoemulsification in cataract and congenital iris coloboma and point out some specific surgical recommendations aimed to minimize its complications. methods : a prospective case series study was conducted on nineteen consecutive patients with cataract and congenital iris coloboma referred to the farabi eye hospital in tehran....

purpose: to investigate central corneal thickness (cct), endothelial cell characteristics and intraocular pressure (iop) in congenital cataract extracted eyes and to compare the results with eyes of normal age and sex matched controls. methods: cct and iop measurements and specular microscopy were performed in 31 eyes of 17 cases of extracted congenital cataracts and 40 eyes of 20 age and sex m...

OBJECTIVES To describe a family in which it was possible to perform prenatal diagnosis of Nance-Horan Syndrome (NHS). METHODS The fetus was evaluated by 2nd trimester ultrasound. The family underwent genetic counseling and ophthalmologic evaluation. The NHS gene was sequenced. RESULTS Ultrasound demonstrated fetal bilateral congenital cataract. Clinical evaluation revealed other family memb...

PURPOSE Active surveillance has not been widely used in ophthalmologic research. The use of capture-recapture analysis to determine completeness of case ascertainment by active surveillance in a national study of congenital cataract is reported. METHODS In 1 year in the United Kingdom, all incident diagnoses of congenital and infantile cataract were notified through independent ophthalmic and...

AIM To evaluate factors associated with the development of strabismus after cataract extraction and primary intraocular lens implantation. METHODS The medical records of 122 patients, aged 1.5mo to 9y, who had undergone cataract extraction with primary intraocular lens implantation between January 1993 and August 2011 were reviewed. Fourteen patients (17 eyes) with strabismus before cataract ...

AIM The aim of this study was to evaluate the long-term visual outcomes and factors affecting visual results in children undergoing secondary intraocular lens (IOL) implantation following primary congenital cataract extraction. METHODS Children with congenital cataracts who underwent secondary IOL implantation for aphakia at the Eye and ENT Hospital of Fudan University between January 1, 2001...

purpose: to compare the results of three-piece and one- piece hydrophobic acrylic posterior chamber intraocular lens (iol) with poly methyl metacrylate (pmma) iol implanted during lensectomy, posterior capsulotomy and anterior vitrectomy for congenital or developmental cataract. methods: this is a historical cohort study conducted on patients with congenital or developmental cataract who underw...

PURPOSE To date, more than thirty nine genetic loci have been associated with congenital cataracts. Despite this progress, current diagnostic techniques are insufficient for unraveling the underlying genetic defect in sporadic patients and small families. In the present manuscript we demonstrate the contribution of routine laboratory tests in the search for genetic defects of childhood cataract...