IMPORTANCE Sensorineural hearing loss (SNHL) is commonly caused by conditions that affect cochlear structures or the auditory nerve, and the genes identified as causing SNHL to date only explain a fraction of the overall genetic risk for this debilitating disorder. It is likely that other genes and mutations also cause SNHL. OBJECTIVE To identify a candidate gene that causes bilateral, symmet...

Sensorineural hearing loss (SNHL) is a common clinical condition resulting from dysfunction in one or more parts in the auditory pathway between the inner ear and auditory cortex. Despite the prevalence of SNHL, little is known about its etiopathology, although several mechanisms have been postulated including ischemia, viral infection or reactivation, and microtrauma. Immune-mediated inner ear...

UNLABELLED Auditory neuropathy spectrum disorder (ANSD) is characterized by impairment of the auditory nerve associated with preservation of outer hair cell function. OBJECTIVE To establish the prevalence of ANSD in subjects with sensorineural hearing loss (SNHL). METHOD This retrospective study was carried out between 2010 and 2012 and included the charts of 2,292 individuals with SNHL. Da...

OBJECTIVE To investigate risk factors for sensorineural hearing loss (SNHL) in children after liver transplantation. DESIGN Retrospective medical record review. SETTING Pediatric tertiary care hospital. PATIENTS One hundred twenty-five consecutive children who received liver transplants between March 1, 1987, and June 30, 1996. MAIN OUTCOME MEASURES The presence of SNHL (bone conduction...

H earing loss is a very common congenital disorder affecting one in 1000 newborns. More than 50% of deafness cases in the paediatric population have a genetic cause with autosomal dominant, autosomal recessive, X-linked, or mitochondrial patterns of inheritance. Mutations in mitochondrial DNA (mtDNA), particularly in the 12S rRNA and tRNA genes, have been found to be one of the most important c...

OBJECTIVE To investigate the hypothesis that second-hand smoke (SHS) exposure is associated with sensorineural hearing loss (SNHL) in adolescents. DESIGN A complex, multistage, stratified geographic area design for collecting representative data from the noninstitutionalized US population. PARTICIPANTS Cross-sectional data from National Health and Nutrition Examination Survey (2005-2006) we...

Hajas et al. recently examined the prevalence of sensorineural hearing loss (SNHL) in patients with mixed connective tissue disease (MCTD) [1]. Auditory symptoms are relatively frequent, but apparently underestimated, in patients with connective tissue disease [2]. SNHL is rapidly progressive and accompanied by vertigo and/or tinnitus in some patients, but it is often asymptomatic. Since SNHL c...

Although many persons with sensorineural hearing loss (SNHL) seeking hearing care do not have active ear disease, audiologists must appreciate the potentially dynamic and treatable nature of some etiologies of SNHL. This is particularly important now as audiologists are increasingly employed in private practice or other clinical settings that may serve as the point of entry for hearing care. In...

Hearing loss (HL) is one of the most common causes of disability, affecting 360 million people according to the World Health Organization (WHO). HL is most frequently of sensorineural origin, being caused by the irreversible loss of hair cells and/or spiral ganglion neurons. The etiology of sensorineural HL (SNHL) is multifactorial, with genetic and environmental factors such as noise, ototoxic...

BACKGROUND Sensorineural hearing loss (SNHL) is one of the major long term side effects from radiation therapy (RT) in nasopharyngeal cancer (NPC) patients. This study aims to review the incidences of SNHL when treating with different radiation techniques. The additional objective is to determine the relationship of the SNHL with the radiation doses delivered to the inner ear. METHODS A retro...