A cell line with immature blast cell morphology was isolated from HL-60 promyelocytic leukemia cell cultures and designated HL-T. This new cell type is biphenotypic, expressing terminal transferase (TdT) together with myelomonocytoid immunologic features. TdT enzymatic activity, undetectable in HL-60, was determined to be 140 to 180 units/10(8) HL-T cells by the dGTP-assay, approximately 20% of...

We have studied the effects of medium conditioned by the human progranulocytic leukemia cell line, HL-60, on the subsequent growth of new inocula of HL-60 cells. When HL-60 cells were cultured at high cell density, optimal growth rate occurred in liquid suspension and confluent colony growth was observed in viscous medium without the addition of conditioned medium. However, when cells were cult...

Survivors of Hodgkin's lymphoma (HL) frequently have many years to experience the long-term toxicities of combined modality therapies. Also, a significant proportion of HL patients will relapse or have refractory disease, and less than half of these patients will respond to current salvage strategies. 30-50% of HL cases are Epstein-Barr virus associated (EBV-positive HL). The virus is localized...

Despite the growing number of heritage language (HL) learners in courses, interaction between second (L2) and HL has not been fully explored research, thus, it still remains unclear whether mixed (L2-HL) or matched (L2-L2, HL-HL) dyads are more beneficial for learning. This study investigates three possible dyad types differ terms form-focused episodes (FFEs) that arose while worked together, a...

miRNAs as one of the potential therapeutic agents have been recently considered for cancer treatment. AS1411 (aptNCL) is a DNA aptamer specifically binding to nucleolin protein on the cancer cell surface with antiproliferative effect. The aim of the study was to develop a conjugate consisted of aptNCL (as targeted delivery of therapeutic agent) and miRNA let-7d (as a tumor suppressor) using two...

while in the midst of a rejection epiria. The degree of specilk reactivity icnts posttransplant nephrectomy or, 'he reactions of peripheral leukocytes ive depletion of cells directed against · example, patient 2 (HL-A2, 28,17, lining (HL-A2, 28;14, 27) was unJd toward targets bearing (HL-AI, , the phenotypes (I-IL-A 2, W32; 8, ). Similarly patient 4 (HL-A 9, 11; · with (HL-A 2, 11 ;W5, W15) de1...

Freshly isolated rat hepatocytes synthesize and secrete hepatic lipase (HL). Comparison of secreted HL with intracellular HL indicates a secretion-linked increase in the specific enzyme activity. (a) Immunotitration with polyclonal anti-HL showed a 3-5-fold lower specific enzyme activity of intracellular HL than of secreted HL. This was confirmed by ELISA using a mixture of monoclonal anti-HL's...

Hepatic lipase (HL) has a well-established role in lipoprotein metabolism. However, its role in atherosclerosis is poorly understood. Here we demonstrate that HL deficiency raises the proatherogenic apoB-containing lipoprotein levels in plasma but reduces atherosclerosis in lecithin cholesterol acyltransferase (LCAT) transgenic (Tg) mice, similar to results previously observed with HL-deficient...

The structures of the first two complexes with bidentate coordination aminoguanidine Schiff base, i.e., 2-acetylpyridine-aminoguanidine (L), are reported. complex formula [Cd2Cl6(HL)2] (1) was obtained in reaction warm aqueous solutions chloride salts Cd(II), Zn(II) and ligand, while cadmium bromide ligand presence deprotonating agent as well ammonium thiocyanate resulted formation which base h...