The type 1 cannabinoid receptor (CB1R) is one of the most abundant G-protein-coupled receptors (GPCRs) in the brain, predominantly localized to axons of GABAergic neurons. Like several other neuronal GPCRs, CB1R displays significant in vitro constitutive activity (i.e., spontaneous activation in the absence of ligand). However, a clear biological role for constitutive GPCR activity is still lac...

The paper deals with the analysis of flux-controlled memristor which is described by its unambiguous charge-flux constitutive relation. The memristor is excited by ideal sinusoidal voltage source in order to sense its typical i – v pinched hysteretic loop. Two equivalent schematics of the transformation of the exciting voltage into the current response are described. The first one is selected f...

Arch dams are generally built in cantilvever monoliths. Vertical contraction joints between monoliths control the stresses due to concrete shrinkage and temperature variations. Past studies in earthquake safety evaluation of the system often show the tensile fracture and local nonlinear deformation of joints. In this paper, some nonlinear joint element constitutive models are presented to exami...

BACKGROUND AND PURPOSE Thermostabilization by mutagenesis is one method which has facilitated the determination of high-resolution structures of the adenosine A2A receptor (A(2A)R). Sets of mutations were identified, which both thermostabilized the receptor and resulted in preferential agonist (Rag23 mutant) or antagonist (Rant5 and Rant21) binding forms as assessed by radioligand binding analy...