van der Meu-len JH, et al. Empirical evidence of design-related bias in studies of diagnostic tests.SORT statement and quality of reports of randomised trials. A comparative before-and-after evaluation. of methodological factors in randomised controlled trials and the association with a journal policy to promote adherence to the Consolidated Standards of Reporting Trials (CONSORT) checklist. Co...

BACKGROUND Of the antiarrhythmic agents currently marketed in Canada, 5 are commonly used to treat atrial fibrillation (AF). The impact of contraindications, warnings and precautions for the use of these drugs in patients with AF is not known. We evaluated the proportion of patients with AF for whom contraindications, warnings and/or precautions might limit the use of these commonly prescribed ...

Laser vision correction (LCV) is a common corneal surgery for the treatment of refractive errors. The rapid development LVC techniques make this procedures safe and efficient. Despite high safety profile surgery, there are however some clinical conditions that constitute absolute or relative contraindication procedures. aim paper was to overview summarise currently known systemic contraindicati...

BACKGROUND The safety of paediatric medications is paramount and contraindications provide clear pragmatic advice. Further advice may be accessed through Summaries of Product Characteristics (SPCs) and relevant national guidelines. The SPC can be considered the ultimate independent guideline and is regularly updated. In 2008, the authors undertook a systematic review of the SPC contraindication...