Increased circulating free fatty acids (FFAs) inhibit both hepatic and peripheral insulin action. Because the loss of effectiveness of glucose to suppress endogenous glucose production and stimulate glucose uptake contributes importantly to fasting hyperglycemia in type 2 diabetes, we examined whether the approximate twofold elevations in FFA characteristic of poorly controlled type 2 diabetes ...

AIMS To examine experiences of primary care providers with six-monthly diabetes monitoring of well-controlled patients. METHODS This study was part of the EFFIMODI study, examining whether six-monthly monitoring of well-controlled (HbA1c ≤58 mmol/mol, systolic blood pressure ≤145 mmHg and total cholesterol ≤5.2 mmol/l) type 2 diabetes patients results in equivalent cardiometabolic control com...

OBJECTIVE To systematically review the available evidence examining the effects of the major antihypertensive drug classes on the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS The Cochrane Controlled Trials Register, Medline, and Embase were searched for English-language case-control, cohort, and randomized controlled trials involving the major antihypertensive classes and reporti...

BACKGROUND The study was conducted to investigate the diet barriers perceived by patients with poorly controlled type 2 diabetes and examine the associations between diet barriers and sociodemographic characteristics, medical condition, and patient-centered variables. METHODS Secondary subgroup analyses were conducted based on the responses of 246 adults with poorly controlled type 2 diabetes...

Abstract This study investigates the role of psychological flexibility in relation to glycaemic control (HbA1c) and quality life among adolescents with poorly-controlled diabetes. Adolescents (n = 65, aged 12–16 years) completed Children Mindfulness Measure (CAMM), Diabetes Acceptance Action Scale for (DAAS), Depression (RBDI), Health-Related Quality Life (KINDL-R). HbA1c values were collected ...

OBJECTIVE We report an unusual case of extensive xanthogranulomatous orchitis (XGO) in association with poorly controlled diabetes mellitus. CLINICAL PRESENTATION AND INTERVENTION A 65-year-old Kuwaiti man with poorly controlled diabetes mellitus presented with a painful left testicular swelling of 1 year duration. Testicular tumor markers were normal. Scrotal ultrasonography showed a mass le...

BACKGROUND This paper presents the pilot study and protocol for a randomised controlled trial to test the effectiveness of a psychological, family-based intervention to improve outcomes in those with poorly controlled type 2 diabetes. The intervention has been designed to change the illness perceptions of patients with poorly controlled type 2 diabetes, and their family members. It is a complex...

Sixty years after its introduction in the therapeutic arsenal of type 2 diabetes, metformin remains first-line treatment diabetes according to national and international guidelines. Numerous obser¬vational studies have suggested that may exert beneficial effects on - nondiabetes related comorbidi¬ties, including cardiovascular, hepatic, neoplastic, infectious dis¬eases. However, direct evidence...

OBJECTIVE Eligibility criteria for bariatric surgery in diabetes include BMI ≥35 kg/m(2) and poorly controlled glycemia. However, BMI does not predict diabetes remission, and thus, predictors need to be identified. RESEARCH DESIGN AND METHODS Seven hundred twenty-seven patients were included in a database merged from the Swedish Obese Subjects (SOS) study and two randomized controlled studies...