Islet amyloid polypeptide (IAPP) (amylin), the major component of islet amyloid, is produced by cleavage at the COOH- and NH(2)-termini of its precursor, proIAPP, likely by the beta-cell prohormone convertases (PC) 1/3 and PC2. Mice lacking PC2 can process proIAPP at its COOH- but not its NH(2)-terminal cleavage site, suggesting that PC1/3 is capable of initiating proIAPP cleavage at its COOH-t...

Two new C60-based n-type materials, EGMC-OH and EGMC-COOH, functionalized with hydrophilic triethylene glycol groups (TEGs), have been synthesized and employed in conventional polymer solar cells. With the assistance of the TEG-based surfactant, EGMC-OH and EGMC-COOH can be dissolved in highly polar solvents to implement the polar/nonpolar orthogonal solvent strategy, forming an electron modifi...

In this studies removal of some ions such as Pb(II), Cd(II) and Cu(II) by single walled carbon nanotubes (SWCNTs) and carboxylate functionalized (SWCNTs-COOH) from aqueous solution were studied. The effect of pH, contact time, initial concentration, ionic strength, temperature, equilibrium, models and thermodynamic parameters on the removal of ions was investigated. The results indicated that L...

The COOH terminus of decay accelerating factor (DAF) contains a signal that directs attachment of a glycophospholipid (GPI) membrane anchor. To define this signal we deleted portions of the DAF COOH terminus and expressed the mutant cDNAs it CV1 origin-deficient SV-40 cells. Our results show that the COOH-terminal hydrophobic domain (17 residues) is absolutely required for GPI anchor attachment...

Thermoplastic polyolefin (TPO) has gained considerable attention because of having a combination rubbery and thermoplastic properties ease production. Their excellent weather resistance, low density, relatively cost make them attractive materials for the automotive, electrical, footwear industries membranes water treatment. main shortcomings are poor mechanical properties, especially at tempera...

Coenzyme Q10 (CoQ10) has a wide range of physiological functions and therapeutic value. However, its biomedical application as health product or drug is limited by insolubility low bioavailability. Single-walled carbon nanotubes (SWCNTs) have attracted great interest for agent delivery due to their unique properties. In this study, the pristine SWCNTs are purified with different oxidizing acid,...

Hearts from insulin-resistant type 2 diabetic db/db mice exhibit features of a diabetic cardiomyopathy with altered metabolism of exogenous substrates and reduced contractile performance. Therefore, the effect of chronic oral administration of 2-(2-(4-phenoxy-2-propylphenoxy)ethyl)indole-5-acetic acid (COOH), a novel ligand for peroxisome proliferator-activated receptor-gamma that produces insu...

This study evaluated the biomineralization and dentinal tubules occlusion abilities of the carboxyl-terminated polyamidoamine dendrimer (PAMAM-COOH) on human demineralized dentin in vivo at different time points. Demineralization dentin model with and without treated with PAMAM-COOH were sutured to the interior side of the rat's cheeks, that was incubated in the rats' saliva for 2, 4 and 6 week...

The character and degree of influence carboxylic acid groups (COOH) on the sensory properties (particularly chemoresistive response) a gas sensor based zigzag armchair graphene nanoribbons are shown. Using density functional theory (DFT) calculations, it is found that more promising to use carboxylated nanoribbon as element. response these higher than uncarboxylated nanoribbons. It also reveale...

Polyphosphazene was synthesized by ultrasonic using 4,4-diaminodiphenyl ether and hexachlorocyclotriphosphazene (HCCP) as precursors. Next, it further carbonized functionalized to prepare the carboxylic-acid N, P co-doped carbon materials (NPCs-COOH). The structure of NPCs-COOH characterized FTIR, SEM XPS. sorption performance for U(VI) in solution were determined under diverse factors includin...