The effects of iron deficiency on the levels of iron, copper, zinc and magnesium in the brain, liver, kidney, heart and lungs of albino rats (Rattus novergicus) was investigated. Forty rats were divided into two groups and the first group was fed a control diet containing 1.09g iron/kg diet while the test group was fed diet containing 9ppm iron/kg diet. Tissue iron level reduced in all the diet...

A study of the effect of certain metals on the prevention of nutritional anemia in the rat has been reported in the preceding paper (4). Animals receiving a mixture of manganese, cobalt, nickel, and zinc with iron developed a progressive anemia and died, whereas those receiving the same mixture with iron and copper developed an abnormally high hemoglobin value at the age of 7 to 9 weeks. After ...

AIMS In Wilson disease (WD), T2/T2*-weighted (T2*w) MRI frequently shows hypointensity in the basal ganglia that is suggestive of paramagnetic deposits. It is currently unknown whether this hypointensity is related to copper or iron deposition. We examined the neuropathological correlates of this MRI pattern, particularly in relation to iron and copper concentrations. METHODS Brain slices fro...

Bivalent copper and the Schiff's base pyridylalpydidylhydrazine form two compounds, composed respectively of one molecule and of two molecules of the organic compound to one atom of copper, and having ultra violet absorption spectra differing only in the value of the molar extinction coefficients at the absorption maxima, 15,100 and 22,450, respectively at 345 mμ. The respective formation const...

We sought to identify novel genes involved in intestinal iron absorption by inducing iron deficiency in rats during postnatal development from the suckling period through adulthood. We then performed comparative gene chip analyses (RAE230A and RAE230B chips; Affymetrix) with cRNA derived from duodenal mucosa. Real-time PCR was used to confirm changes in gene expression. Genes encoding the apica...

Iron, zinc, and copper play fundamental roles in eucaryotes and procaryotes, and their bioavailability regulates host-pathogen interactions. For intracellular pathogens, the source of metals is the cytoplasm of the host, which in turn manipulates intracellular metal traffic following pathogen recognition. It is established that iron is withheld from the pathogen-containing vacuole, whereas for ...

Great attention should be paid now to simultaneously removing common pollutants, especially inorganic pollutants such as nitrate and heavy metals, as individual removal has been investigated extensively. Removing common pollutants simultaneously by iron metal is a very effective alternative method. Near neutral pH, heavy metals, such as copper and nickel, can be removed rapidly by iron metal, w...

this study was conducted to determine the spatial variability and mapping of available micronutrients iron, zinc, copper and manganese on 20,000 hectares of soils in south of tehran lands in order to identify deficiency, enough and toxicity areas. 196 surface soil samples (0-25cm) to a regular grid network of 1000×1000m were collected and extracted by dtpa and tea and concentrations of elements...

The importance of iron and copper in cancer biology has been well established. Iron plays a fundamental role in cellular proliferation and copper has been shown to be a significant cofactor for angiogenesis. Early observations with the chelator used for the treatment of iron overload, desferrioxamine, showed that it had promise as an anticancer agent. These results sparked great interest in the...