The coordinatively unsaturated copper (II) complexes of 1,3-bis(2'-pyridyl)-1,2-diaza-2- butene with different ancillary anions were synthesized which can bind to copper centers of tyrosinase enzyme. The compounds were found to exhibit inhibitory activities against mushroom tyrosinase and the nature and extent of inhibition is modulated according to the type of ancillary anions.

Copper sulfate is widely used as a fungicide and pesticide. Acute copper poisoning rare but potentially lethal in severe cases. can lead to cellular damage of red blood cells, hepatocytes, myocytes. Toxic effects include intravascular hemolysis, acute tubular necrosis and, rhabdomyolysis. A 76-year-old man presented with vomiting epigastric pain. He had ingested copper-containing (about 13.5 g ...

Under appropriate conditions, deficiencies of certain minerals and vitamins as well as high intakes of dietary fat increase the toxicity of a given dose of lead in experimental animals. The severity of lead poisoning can also be increased by the consumption of either deficient or excessive levels of protein. Mineral deficiencies appear to have some of the most profound effects on lead toxicity,...

Acetaminophen toxicity has become a leading cause of both accidental and intentional poisoning, and is now the most common cause of acute liver failure in the United States. Acetaminophen poisoning is thus a significant burden on the health care system and a cause of considerable morbidity and mortality. Tetrathiomolybdate is a fast acting anticopper drug developed for Wilson’s disease. However...