According to classical motive disposition theory, individuals differ in their propensity to derive pleasure from affiliative experiences. This propensity is considered a core process underlying the affiliation motive and a pervasive cause of motivated behavior. In this study, we tested these assumptions. We presented participants with positive affiliative stimuli and used electromyography to re...

This study provides a demonstration in the rat of a clear genetic difference in the propensity for addiction-related behaviors following prolonged cocaine self-administration. It relies on the use of selectively bred high-responder (bHR) and low-responder (bLR) rat lines that differ in several characteristics associated with "temperament," including novelty-induced locomotion and impulsivity. W...

If changes in thermoregulation mediate sleepiness induced by sedative/hypnotics, then a reduction in the soporific efficacy (tolerance) of these agents may be accompanied by a concomitant reduction in their thermoregulatory effects. We compared the thermoregulatory and soporific effects of acute temazepam (30 mg at 1400) in 11 young male subjects before and immediately after 7 consecutive days ...

Hepatitis C virus (HCV) infection is characterized by a strong propensity toward chronicity. During chronic HCV infection, HCV core protein is implicated in deregulating cytokine expression that associates with chronic inflammation. A20 is known as a powerful suppressor in cytokine signaling, in this study, we explored the A20 expression in macrophages induced by HCV core protein and the involv...

In this article, we have demostrated the application of two newly proposed estimators which accounts for lack of overlap under propensity score matching on a case study involing the analysis of health expenditure data for the United States. Citation: Baser, Onur, (2007) "Propensity Score Matching with Limited Overlap." Economics Bulletin, Vol. 9, No. 8 pp. 1-8 Submitted: March 17, 2007. Accepte...

Background: It is often the case in research that groups of interest represent a small number of records or have other distinct characteristics. For example, the group may consist of those with extreme values (either high or low), such as Opioid problem users (Subramaniam, Ives, Stitzer, & Dennis, 2010), or have other unique characteristics such as those who are deaf or hard of hearing (Titus, ...

This paper examines the foundations for comparing individuals and treatment subjects in experimental and other program evaluation contexts. We raise the question of multiattribute "characterization" of individuals both theoretically and statistically. The paper examines the information basis of characterizing individuals and offers alternatives motivated by welfare and decision theories. The pr...

The question whether the telecommunication sector has been really supporting poverty alleviation and increasing welfare at the household level, in terms of an additional income in Indonesia is still undisclosed. This paper aims at investigating whether the mobile phone access and the uses on productive features/content/services have brought many benefits to the households in terms of an additio...

p53 protein has about thirty phosphorylation sites located at the N- and C-termini and in the core domain. The phosphorylation sites are relatively less mutated than other residues in p53. To understand why and how p53 phosphorylation sites are rarely mutated in human cancer, using a bioinformatics approaches, we examined the phosphorylation site and its nearby flanking residues, focusing on th...

Proteins can be very tolerant to amino acid substitution, even within their core. Understanding the factors responsible for this behavior is of critical importance for protein engineering and design. Mutations in proteins have been quantified in terms of the changes in stability they induce. For example, guest residues in specific secondary structures have been used as probes of conformational ...