We report a new R package implementing the clustering of regression models (CORM) method for clustering genes using gene expression data and provide data examples illustrating each clustering function in the package. The CORM package is freely available at CRAN from http://cran.r-project.org.

The physiological gaseous molecule, carbon monoxide (CO) becomes a subject of extensive investigation due to its vasoactive activity throughout the body but its role in gastroprotection has been little investigated. We determined the mechanism of CO released from its donor tricarbonyldichlororuthenium (II) dimer (CORM-2) in protection of gastric mucosa against 75% ethanol-induced injury. Rats w...

The development of carbon monoxide-releasing molecules (CO-RMs) in recent years helped to shed more light on the diverse range of anti-inflammatory and cytoprotective activities of CO gas. In this study, we examined the effect of a ruthenium-based water-soluble CO carrier (CORM-3) on lipopolysaccharide (LPS)and interferon(INF)-induced inflammatory responses in BV-2 microglial cells and explored...

The aim of the present study was to investigate whether carbon monoxide (CO) induces changes in ion transport across the distal colon of rats and to study the mechanisms involved. In Ussing chamber experiments, tricarbonyldichlororuthenium(II) dimer (CORM-2), a CO donor, evoked a concentration-dependent increase in short-circuit current (I(sc)). A maximal response was achieved at a concentratio...

in order to investigate the effects of corm tunic, corm weight and drought stress on saffron (crocus sativus l.), an experiment was conducted at the greenhouse of ferdowsi university of mashhad, iran. treatment were combination of four corm weights range (2-4, 4-6, 6-8 and 8-10 g), two levels of water availability (100% field capacity and drought) and two levels of corm tunic (natural corm with...

The development of carbon monoxide-releasing molecules (CO-RMs) in recent years helped to shed more light on the diverse range of anti-inflammatory and cytoprotective activities of CO gas. In this study, we examined the effect of a ruthenium-based water-soluble CO carrier (CORM-3) on lipopolysaccharide (LPS)- and interferon-gamma (INF-gamma)-induced inflammatory responses in BV-2 microglial cel...

Carbon monoxide (CO) generated by the enzyme heme oxygenase during the breakdown of heme is known to mediate a number of biological effects. Here, we investigated whether CO liberated from a water-soluble CO-releasing molecule (CO-RM) is capable of modulating leukocyte-endothelial interactions. Tricarbonylchoro(glycinato)ruthenium (II) (CORM-3), a fast CO releaser, proved to be anti-inflammator...

Neuropathic pain is still an extremely important problem in today's medicine because opioids, which are commonly used to reduce pain, have limited efficacy in this type of pathology. Therefore, complementary therapy is needed. Our experiments were performed in rats to evaluate the contribution of the purinergic system, especially P2X4 receptor (P2X4R), in the modulation of glia activation and, ...

Taro (ColocasiaesculentaL. Schott) is a perennial root crop that belongs to Araceace family. It is widely cultivated as a staple food in Africa, Asia and pacific Islands. Despite its importance, there is limited information on many aspects of the crop. In order to obtain data that can support improved and sustainable taro production, a field trial was conducted to study the effects of ...

Objective: Taro (Colocasia esculenta L. Schott) is a perennial root crop that belongs to Araceace family.  It is widely cultivated as a staple food in Africa, Asia and pacific Islands. Despite its importance, there is limited information on many aspects of the crop. In order to obtain data that can support improved and sustainable taro production, a field trial was conducted to study t...