Corneal deposits after the topical use of ofloxacin in two children with vernal keratoconjunctivitis Topical fluoroquinolones are broad spectrum, bactericidal agents with activity against both Gram positive and Gram negative corneal pathogens. Single drug administration with topical fluoroquinolones has been effectively used in treatment of bacterial ulcerative kera-titis. The drugs are safe, b...

Anterior segment optical coherence tomography (AS-OCT) was recently developed and has become a crucial tool in clinical practice. AS-OCT is a noncontact imaging device that provides the detailed structure of the anterior part of the eyes. In this review, the author will discuss the various clinical applications of AS-OCT, such as the normal findings, tear meniscus measurement, ocular surface di...

Corneal deposits after the topical use of ofloxacin in two children with vernal keratoconjunctivitis Topical fluoroquinolones are broad spectrum, bactericidal agents with activity against both Gram positive and Gram negative corneal pathogens. Single drug administration with topical fluoroquinolones has been effectively used in treatment of bacterial ulcerative kera-titis. The drugs are safe, b...

PURPOSE Macular corneal dystrophy (MCD) is an autosomal recessive disorder characterized by progressive central haze, confluent punctate opacities and abnormal deposits in the cornea. It is caused by mutations in the carbohydrate sulfotransferase-6 (CHST6) gene, encoding corneal N-acetyl glucosamine-6-O-sulfotransferase (C-GlcNAc-6-ST). We screened the CHST6 gene for mutations in Indian familie...

Causes of Melanosis other than Chlorpromazine THE pathological deposition of melanin is rarely seen in the tissues of the eye. Normally, small collections of melanin are sometimes seen in the eyes of Caucasians where the ciliary vessels pierce the sclera near the limbus. Larger collections of melanocytes form a benign naevus which may invade the cornea, or there may be multiple collections of m...

PURPOSE To describe a case of severe corneal granular dystrophy with clinicopathologic and molecular genetic findings. METHODS The DNAs of a 53-year-old male patient suffering from corneal granular dystrophy and nonaffected family members were analyzed by molecular genetic methods. Clinical features, and histopathologic and immunohistochemical findings from the penetrating keratoplasty specim...

We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan(TM):WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histopathologically and ultrastructurally investigated. According to the results, W...