BACKGROUND For bacterial infections, the susceptibility to antibiotics in vitro has been associated with clinical outcomes in vivo, although the importance of minimum inhibitory concentration (MIC) has been debated. In this study, we analyzed the association of MIC on clinical outcomes in bacterial corneal ulcers, while controlling for organism and severity of disease at presentation. METHODS...

purpose: to report the outcomes of pediatric penetrating keratoplasty (pk) performed in labafinejad medical center, a tertiary referral ophthalmology center, between 2001 and 2012. methods: in this retrospective interventional case series, medical records of all pediatric patients (age≤12 years) who underwent primary pk were reviewed. age at the time of surgery, indications for keratoplasty, po...

A 30 year old female presented with a large post traumatic iris cyst obstructing the visual axis, with a corneal scar inferiorly. Anterior segment optical coherence tomography (AS-OCT) was done to identify the areas of corneal attachment and locate the thinnest area of the cyst. Nd:YAG laser iridocystotomy performed subsequently resulted in immediate deflation of the cyst, excellent restoration...

Whole neonate rabbit corneas and adult corneas containing 2-week-old scars were incubated in the presence of [14C] glycine. Radiolabeled collagen extracted from the corneas and scar tissue were analyzed by sodium dodecylsulfate/polyacrylamide gel electrophoresis and fluorography to determine the types and relative quantity of collagen polypeptides present and synthesized by these tissues. In ad...

The ocular characteristics and responses were examined in patients who had undergone extracapsular cataract extraction (ECCE), intracapsular cataract extraction (ICCE) and penetrating keratoplasty (PKP) in one eye only. In each of the three groups, corneal sensitivity (the inverse of corneal touch threshold), oxygen uptake rate, and endothelial cell density were lower in the operated eye than i...

BACKGROUND Indications for corneal transplantation in developed and developing nations differ according to the different spectrum of corneal disease in each country. OBJECTIVE The purpose of this study is to analyze the changing indications and surgical techniques for corneal transplantation over the past 20 years at a tertiary referral center in Turkey. METHODS We retrospectively reviewed ...

PURPOSE To summarize the current concepts and recent literature regarding the epidemiology, pathogenesis, imaging modalities, and treatment of acute hydrops in keratoconus. DESIGN Perspective. METHODS Review and synthesis of selected literature, with interpretation and perspective. RESULTS Acute corneal hydrops is an incompletely understood complication of keratoconus, characterized by ma...

April 2011, Vol. 101, No. 4 SAMJ The patient sustained an accidental injury that resulted in broken glass causing a penetrating eye injury in her left eye. A corneal laceration with iris prolapse was not identified at a secondary hospital. Eight weeks after the injury, she presented at Groote Schuur Hospital complaining of decreased vision and severe pain in both eyes. The diagnosis was sympath...

PURPOSE To report the clinical course, microbiologic findings, treatment, and outcomes of overnight orthokeratology associated microbial keratitis. METHODS Four cases of overnight orthokeratology associated microbial keratitis are reported. RESULTS Four patients aged 14-23 years (mean 18 years) who had central or paracentral corneal ulcers were included. Visual acuity at presentation ranged...

PURPOSE Corneal myofibroblasts differentiated from activated corneal stromal cells are the major cellular sources of extracellular matrix synthesis for the repair of corneal injury. In this study, the effects of histone deacetylase (HDAC) inhibitors on the activation, proliferation, migration and senescence of corneal stromal cells were evaluated. METHODS Primary human and mouse corneal strom...