Corneal collagen cross-linking with riboflavin and UVA light is a new therapeutic method for increase the biomechanical stability of the cornea through induction of new additional links between collagen fibers. The aim of this paper is to show the mechanism of action of this therapeutically method in different corneal diseases, for which this method can be applied: corneal ectasia, bullous kera...

AIMS This study's objective was to evaluate the tolerance and safety of a new ophthalmic solution based on ReGeneraTing agent (RGTA) technology in a pilot noncontrolled exploration on compassion use for corneal ulcers and severe chronic dystrophies resistant to the usual treatments. RATIONALE RGTAs are large biopolymers engineered to replace heparan sulfates specifically bound to matrix prote...

MULES (1894) wrote that where " the action of micro-organisms on an abraded surface may cause or is causing destructive changes " the indications would be to remove the irritating elements and allow the natural process of repair to heal the breach of surface ". He sought to achieve this by placing a gelatine wafer impregnated with iodoform on the corneal surface and keeping the eye bandaged. He...

Introduction. The objective was to evaluate the efficacy of active pedicle epithelial flap transposition combined with amniotic membrane transplantation (AMT) in treating nonhealing corneal ulcers. Material and Methods. Eleven patients (11 eyes) with nonhealing corneal ulcer who underwent the combined surgery were included. Postoperatively, ulcer healing time was detected by corneal fluorescein...

P. aeruginosa and S. pneumoniae are major bacterial causes of corneal ulcers in industrialized and in developing countries. The current study examined host innate immune responses at the site of infection, and also expression of bacterial virulence factors in clinical isolates from patients in south India. Corneal ulcer material was obtained from 49 patients with confirmed P. aeruginosa and 27 ...

To the Editor: The case series study by Ehlers et al,1 which appeared in the September 2009 issue of the Journal of Refractive Surgery, presented the results of ribofl avin-ultraviolet A (UVA) treatment in the management of edema and nonhealing ulcers of the cornea. Both the effi cacy and safety of this method in the treatment of persisting nonhealing corneal ulcers were remarkable; 6 of 14 eye...

This study was performed to analyze risk factors for and treatment results of ulcerative keratitis. The mean age (±SD) of 32 dogs with ulcerative keratitis was 3.59 (±2.97) years and the most commonly affected breed was the Shih-tzu (50%). Keratoconjunctivitis sicca (31%) was the predominant cause of ulcerative keratitis. Superficial corneal ulcers (in 44% of animals) treated with medication al...

Novel Telemedicine Device for Diagnosis of Corneal Abrasions andUlcers in Resource-Poor Settings Corneal ulcers are a significant cause of corneal blindness worldwide.1 Normally, traumatic corneal damage and secondary infections are diagnosed by an ophthalmologist via slitlamp examination. However, limited health care resources in developing regions may delay diagnosis and treatment, increasing...