Very early reperfusion after coronary occlusion can reduce infarct size and preserve left ventricular function. Whether later reperfusion is of benefit is unclear. We studied the effect of very early reperfusion with myocardial salvage and "late" reperfusion without myocardial salvage on infarct expansion and aneurysm formation. Sixty-eight rats underwent left coronary artery ligation and were ...

Aneurysmal circumflex coronary artery fistula connected to the coronary sinus is a rare clinical entity that usually remains asymptomatic until later in life. The timing of surgical treatment for asymptomatic patients is crucial. The decision to leave or exclude the aneurysmatic coronary artery following ligation of the fistula is controversial. Herein, we report the successful management of a ...

Penetrating trauma to the chest leading to coronary artery injury is associated with a high mortality rate, especially in the case of injury to the left anterior descending (LAD) coronary artery. The mortality rate remains high whether they are managed with primary ligation or with coronary artery bypass grafting using conventional cardiopulmonary bypass techniques. We report a case of proximal...

Background: Anomalous origin of the right coronary artery from left sinus Valsalva (ARCA) is a rare anomaly. Surgery recommended in symptomatic patients, while optimal surgical approach controversial.
 Case presentation: We present case an ARCA 56-year-old male who was managed with bypass grafting using internal mammary and ligation proximal artery. The patient remained asymptomatic after ...

OBJECTIVE To compare in vivo and in vitro haemodynamic performance in two models of experimental cardiac failure. To validate echocardiography as a means of non-invasive assessment of left ventricular dysfunction in rabbits. METHODS Cardiac failure was induced by doxorubicin injection (1-1.25 mg.kg-1 twice weekly for 8 weeks (n = 16)) or coronary ligation (n = 12), with 12 controls. Left vent...

This study was conducted to determine whether or not a low concentration of carboxyhemoglobin influences the extent and severity of myocardial ischemia caused by coronary ligation. In 10 dogs, electrograms were recorded from 6 epicardial electrodes mounted on the anterior surface of the left ventricle and distributed over the area normally perfused by the lighted branch of the left anterior des...

We report two cases of successful emergency ligation of anomalous left coronary artery arising from the pulmonary artery (ALCAPA) in patients with previous cardiac arrest. Both patients had regained marginal cardiac output after cardiopulmonary resuscitation and had maximal doses of inotropic support. The ALCAPA ligation was then performed as a life-saving procedure in the absence of any kind o...

This study investigates the possible role of oscillatory release of calcium from sarcoplasmic reticulum in the genesis of ventricular arrhythmias during acute myocardial ischemia and reperfusion in isolated rat hearts. We used ryanodine and caffeine, which are known to modulate the oscillatory release of calcium from sarcoplasmic reticulum. During 30 minutes of left main coronary artery ligatio...

Strong cardioprotective properties of erythropoietin (EPO) reported over the last 10 years have been difficult to translate to clinical applications for ischemic cardioprotection owing to undesirable parallel activation of erythropoiesis and thrombogenesis. A pyroglutamate helix B surface peptide (pHBP), recently engineered to include only a part of the EPO molecule that does not bind to EPO re...

to evaluate the prognostic significance of clinicopathological measurement in the diagnosis of acute myocardial infarction (mi) in sheep, acute mi was induced by ligation of left anterior descending coronary artery (lad). for this purpose, twenty four healthy sheep were divided into the sham-operated or control group (group i, thoracotomy without mi) and the experimental group (group ii, with m...