A new sustainable green protocol for obtaining polyethylene glycol (PEG) conjugates, with a prototype molecule, which in this work was coumarin, by means of click chemistry is presented. The organic solvents commonly used type reaction were replaced supercritical carbon dioxide (scCO2). synthesis and characterization PEG-coumarin successfully reported using FTIR, 1H NMR, MALDI TOF. Subsequently...

Lipids and coumarin were extracted from cumaru seeds using Soxhlet extraction (SE) with ethanol (EtOH) ethyl acetate (EtOAc), scCO 2 , +EtOH +EtOAc, either in a single or sequential stages, PLE EtOH. ScCO +EtOAc provided yields 28% to 31%, independently of the conditions employed, provide top yield 38%, at 25 MPa 80 ºC. Extraction enhanced by three extractions, resulting 44.0% 56.5% for +EtOH, ...

Coumarin derivatives, such as warfarin, acenocoumarol and phenprocoumon, are commonly prescribed as oral anticoagulants for the treatment of thromboembolic disorders. Therapy with coumarin derivatives is most effective when the international normalized ratio (INR) is kept within a narrow range. Prescribing of these drugs is difficult because of their narrow therapeutic window and the wide inter...

Coumarin-induced mouse Clara cell toxicity is thought to result from the local formation of coumarin 3,4-epoxide (CE). However, this toxicity is not observed in the rat, indicating species differences in coumarin metabolism. The purpose of the present work was to characterize the in vitro kinetics of coumarin metabolism in mouse, rat, and human whole lung microsomes, and to determine whether sp...

Effect of addition of a permeabilizing agent dimethyl sulfoxide (DMSO) and a solid adsorbent, XAD -7, on growth and coumarin production in hairy root cultures of C. intybus was studied. Continuous permeabilization of the hairy root cultures of C. intybus with DMSO has been shown to be an effective strategy for enhanced release of coumarins while preserving the root viability. DMSO at 0.2% (v/v)...

Cinnamon bark is commonly used in traditional Japanese herbal medicines (Kampo medicines). The coumarin contained in cinnamon is known to be hepatotoxic, and a tolerable daily intake (TDI) of 0.1 mg/kg/day, has been quantified and used in Europe to insure safety. Risk assessments for hepatotoxicity by the cinnamon contained in foods have been reported. However, no such assessment of cinnamon ba...

The asymmetric unit of the title compound, {[Na(C(9)H(6)O(3))(H(2)O)(3)](C(9)H(5)O(3))·H(2)O}(n), contains two crystallographically independent Na atoms, two 7-hy-droxy-coumarin ligands, six coordinated water mol-ecules, two 7-hy-droxy-coumarin anions and two uncoordinated water mol-ecules. Both Na atoms exhibit a distorted octa-hedral coordination geometry and are coordinated by five water O a...

Coumarin oral anticoagulant drugs have proven to be effective for the prevention of thromboembolic events. World-wide, warfarin is the most prescribed drug. In Europe, acenocoumarol and phenprocoumon are also administered. Yet it has been proven that variant alleles of the VKORC1 and CYP2C9 genotypes influence the pharmacokinetics and pharmacodynamics of these drugs. The combination of these tw...

Coumarin, the parent compound of warfarin, has been observed to stimulate macrophages, increase phagocytosis, and induce changes in lymphocyte-mitogen responsiveness in cancer patients. Coumarin has been reported to have antitumor activity in human melanomas and renal cancer when used in conjunction with the 11-2antagonist, cimetidine. We have observed that coumarin has antiprostatic activity i...

In the structures of the two title coumarin derivatives, C14H12O6, (1), and C20H16O6, (2), one with acetate and the other with pent-4-ynoate substituents, both the coumarin rings are almost planar. In (1), both acetate substituents are significantly rotated out of the coumarin plane to minimize steric repulsions. One acetate substituent is disordered over two equivalent conformations, with occu...