We propose a new and effective statistical framework for identifying genome-wide differential changes in epigenetic marks with ChIP-seq data or gene expression with mRNA-seq data, and we develop a new software tool EpiCenter that can efficiently perform data analysis. The key features of our framework are: (i) providing multiple normalization methods to achieve appropriate normalization under d...

BACKGROUND Fresh-frozen plasma (FFP) is frequently transfused to patients with mild prolongation of coagulation values under the assumption that FFP will correct the coagulopathy. There is little evidence to support this practice, however. To determine the effect of FFP on coagulation variables and correlation with bleeding in patients with mildly prolonged coagulation values, a prospective aud...

BACKGROUND Although antiretroviral therapy has the ability to fully restore a normal CD4(+) cell count (>500 cells/mm(3)) in most patients, it is not yet clear whether all patients can achieve normalization of their CD4(+) cell count, in part because no study has followed up patients for >7 years. METHODS Three hundred sixty-six patients from 5 clinical cohorts who maintained a plasma human i...

By developing data augmentation methods unique to the negative binomial (NB) distribution, we unite seemingly disjoint count and mixture models under the NB process framework. We develop fundamental properties of the models and derive efficient Gibbs sampling inference. We show that the gamma-NB process can be reduced to the hierarchical Dirichlet process with normalization, highlighting its un...

This paper presents the derivation and performance results of several new three-dimensional topologies. Various transformations can be applied to the conventional six-neighbor mesh in order to construct these topologies, which vary both in number of neighbors (degree) and logical connectivity. Analysis shows that after normalization for constant pin-count, lower-degree topologies yield lower la...

We demonstrate that a proper control sample correlates linearly with the background parts of its corresponding ChIP sample. In the following examples, we first draw the original ChIP vs control bins counts to show the over-abundance of high ChIP count bins due to binding signals. Then we filter the strong binding signals by calling peaks with SPP (Kharchenko et al., 2008) at FDR 0.1 level and e...

Floating point addition/subtraction has been designed in literature. The methods involved two’s complements add/subtract logic and XOR for counting leading zeroes. This paper proposes algorithm to perform add/subtract operation using one’s complement and counting leading zeroes for normalization using NOR operation as reduction operator for two bits of mantissa at a time. The proposed model is ...

We report the case of a 69-year-old man with acute pulmonary echinococcosis. A computed tomographic scan of the thorax revealed the presence of multiple nodules in both lungs, and laboratory tests showed eosinophilia and the presence of antibodies against Echinococcus granulosus. Therapy with albendazole led to resolution of the pulmonary nodules and a normalization of the white cell count. To ...

Eosinophilia is common in childhood, and in most cases it is mild and of limited clinical relevance, being often secondary to allergy or infections. In rare cases, eosinophilia may be idiopathic or related to neoplastic aetiology. When severe and protracted, it can cause potentially irreversible organ or system damage, whose prevention is the first priority in the clinical management of hypereo...

Felty's syndrome is a rare disorder characterized as a systemic manifestation of severe rheumatoid arthritis associated with granulocytopenia and splenomegaly. We report a retrospective analysis of a series of seven patients treated successfully with low-dose methotrexate. leading to sustained clinical improvement (number of swollen joints) and normalization of the granulocyte count for an obse...