cox 2 inhibitors

As a continuous research for discovery of new COX-2 inhibitors, chemical synthesis, in vitro biological activity and molecular docking study of anew group of 1,4-dihydropyridine (DHP) derivatives were presented. Novel synthesized compounds possessing a COX-2 SO2Me pharmacophore at the para position of C-4 phenyl ring, different hydrophobic groups (R1) at C-2 position and alkoxycarbonyl groups (...

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A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and −2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors

Journal: :Journal of Biological Chemistry 1996

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Gastrointestinal Tolerability of the Selective Cyclooxygenase-2 (COX-2) Inhibitor Rofecoxib Compared With Nonselective COX-1 and COX-2 Inhibitors in Osteoarthritis

Journal: :Archives of Internal Medicine 2000

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Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: Facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors

Journal: :Proceedings of the National Academy of Sciences 2000

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celecoxib treatment alters p53 and mdm2 expression via cox-2 crosstalk in a549 cells

Journal: :iranian journal of pharmaceutical research 0

mehdi gharghabi department of toxicology-pharmacology, school of pharmacy, tehran university of medical sciences, tehran, iran farhang rezaei department of toxicology-pharmacology, school of pharmacy, tehran university of medical sciences, tehran, iran fereshteh mir mohammadrezaei department of biology, faculty of science, university of mazandaran, mazandaran, babolsar, iran mohammad hossein ghahremani tehran university of medical sciences

cyclooxygenase-2 (cox-2) has a pivotal role in the pathogenesis of the lung cancer. it is known that cox-2 negatively regulates the activity of a number of tumor suppressors, including p53. consequently, inhibition of cox-2 signaling is anticipated to be a promising approach to stabilize p53 functionality. in this regard, we investigated the effect of cox-2 signaling blockade on p53 and cox-2 e...

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