Selective serotonin reuptake inhibitors (SSRIs) are the only effective pharmacological treatments for obsessive-compulsive disorder (OCD). Nonetheless, their generally limited efficacy, side-effects, and delayed onset of action require improved medications for this highly prevalent disorder. Preclinical and clinical findings have suggested serotonin2C (5-HT2C) receptors as a potential drug targ...

The tuning of the transient-stereopsis system to luminance contrast and spatial-frequency (SF) was investigated with narrow-band gabor targets with a constant sigma of 1 degree. They were presented for brief (140 ms) durations and subtended a large (6 degrees) disparity. When dichoptic gabor stimuli were matched in SF (0-5 cpd), transient stereo performance was either uniform across SF or great...

Collaborative Product Development (CPD) is an engineering process that involves decision-making through iterative communication and coordination among product designers throughout the lifecycle of the product. The high level of collaboration and communication of a CPD environment requires a robust Distributed Information System. In this paper, we review existing research related to CPD and prop...

Although Rh(I)Cl(CO)(cpd) (cpd = cyclopentadienone) complexes were identified more than 40 years ago, their exact structures have not been determined because of the polymeric nature of these complexes. We determined the structure of [Rh(I)Cl(CO)(cpd)](2), which was formed by the reaction of [Rh(cod)Cl](2) with a 1,6-diyne under CO. In addition, based on determination of the structure of the [Rh...

The CPD provider, VET Trust, was set up by a group of vets nearly 25 years ago with the aim of making CPD accessible to vets and veterinary nurses in Scotland. Kathleen Robertson reports on the Trust's aims and its newest CPD prize.

The purposes of this study were to design a web-based continuing professional development program (CPD) for special educators and to evaluate it effectiveness. School’s faculties instead of programmers developed the CPD program. 17 teachers participated the program and completed the requested tasks finally. These results indicated that this CPD program was effective, usable and feasible based o...

Utilization of chronic peritoneal dialysis (CPD) continues to decline in the United States. Technique failure remains a key factor in this decline. Center size has been associated with technique failure. Afolalu et al. observed that technique failure rates were higher in units with fewer than 25 patients. We wondered if declining CPD utilization rates are reflective of changes in small or large...

We introduce a new method for purifying recombinant proteins expressed in bacteria using a highly specific, inducible, self-cleaving protease tag. This tag is comprised of the Vibrio cholerae MARTX toxin cysteine protease domain (CPD), an autoprocessing enzyme that cleaves exclusively after a leucine residue within the target protein-CPD junction. Importantly, V. cholerae CPD is specifically ac...

A procedure was developed to prepare in large amounts two carboxypeptidases, CPD-I and CPD-II, from Aspergillus niger. They were each shown to be serine proteases and single-chain monomers with molecular masses of ca. 81 kDa and containing 22% carbohydrates. Amino acid analysis, carbohydrate determination, and N-terminal sequencing (20 to 25 residues) were performed on each enzyme. CPD-I showed...