نتایج جستجو برای: cpe

تعداد نتایج: 1934  

Journal: :Infection and immunity 1998
S J Billington E U Wieckowski M R Sarker D Bueschel J G Songer B A McClane

Several Clostridium perfringens genotype E isolates, all associated with hemorrhagic enteritis of neonatal calves, were identified by multiplex PCR. These genotype E isolates were demonstrated to express alpha and iota toxins, but, despite carrying sequences for the gene (cpe) encoding C. perfringens enterotoxin (CPE), were unable to express CPE. These silent cpe sequences were shown to be high...

2016
Laura F. Mataseje Kahina Abdesselam Julie Vachon Robyn Mitchel Elizabeth Bryce Diane Roscoe David A. Boyd Joanne Embree Kevin Katz Pamela Kibsey Andrew E. Simor Geoffrey Taylor Nathalie Turgeon Joanne Langley Denise Gravel Kanchana Amaratunga Michael R. Mulvey

Carbapenemase-producing Enterobacteriaceae (CPE) are increasing globally; here we report on the investigation of CPE in Canada over a 5-year period. Participating acute care facilities across Canada submitted carbapenem-nonsusceptible Enterobacteriaceae from 1 January 2010 to 31 December 2014 to the National Microbiology Laboratory. All CPE were characterized by antimicrobial susceptibilities, ...

Journal: :The Journal of hospital infection 2014
N M Hanemaaijer R H T Nijhuis B J Slotboom E M Mascini A A van Zwet

Rapid identification of patients colonized with carbapenemase-producing Enterobacteriaceae (CPE) is essential to prevent introduction and the spread of CPE in the hospital. This article presents the results of a new screening method to detect patients colonized with CPE within 24h after hospital admission. From high-risk patients rectal and throat swabs were collected and incubated overnight, a...

2014
Azila Abdul Karim Azrina Azlan Amin Ismail Puziah Hashim Siti Salwa Abd Gani Badrul Hisyam Zainudin Nur Azilah Abdullah

BACKGROUND Cocoa pod is an outer part of cocoa fruits being discarded during cocoa bean processing. Authors found out that data on its usage in literature as cosmetic materials was not recorded in vast. In this study, cocoa pod extract was investigated for its potential as a cosmetic ingredient. METHODS Cocoa pod extract (CPE) composition was accomplished using UHPLC. The antioxidant capacity...

2016
Akiko Mizutani Hidetoshi Inoko Masafumi Tanaka

We have identified 88 interactor candidates for human growth hormone (GH) by the yeast two-hybrid assay. Among those, we focused our efforts on carboxypeptidase E (CPE), which has been thought to play a key role in sorting prohormones, such as pro-opiomelanocortin (POMC), to regulated secretory vesicles. We found that CPE co-localizes with and interacts with GH in AtT20 pituitary cells. Downreg...

Journal: :The Journal of biological chemistry 2002
Eduardo A Nillni Weihua Xie Lawrence Mulcahy Vanesa C Sanchez William C Wetsel

Cpe(fat/fat) mice are obese, diabetic, and infertile. They have a mutation in carboxypeptidase E (CPE), an enzyme that converts prohormone intermediates to bioactive peptides. The Cpe(fat) mutation leads to rapid degradation of the enzyme. To test whether pro-thyrotropin-releasing hormone (TRH) conversion to TRH involves CPE, processing was examined in the Cpe(fat/fat) mouse. Hypothalamic TRH i...

Journal: :Molecular cancer therapeutics 2009
Xiaoqin Yuan Xinjian Lin Gerald Manorek Isao Kanatani Lawrence H Cheung Michael G Rosenblum Stephen B Howell

Using gene expression profiling, others and we have recently found that claudin-3 (CLDN3) and claudin-4 (CLDN4) are two of the most highly and consistently up-regulated genes in ovarian carcinomas. Because these tight junction proteins are the naturally occurring receptors for Clostridium perfringens enterotoxin (CPE), in this study, we used the COOH-terminal 30 amino acids of the CPE (CPE(290-...

Journal: :Cancer research 1990
J L Grem C J Allegra

We evaluated the interaction of a biochemically active concentration of cyclopentenyl cytosine (CPE-C), an investigational antimetabolite which inhibits CTP synthetase, on the cytotoxicity of arabinosyl-5-azacytosine (Ara-AC) and 1-beta-D-arabinofuranosylcytosine (Ara-C) in HCT 116 colon carcinoma cells. A 3-h exposure to 0.5 microM CPE-C depleted CTP pools by over 90% and decreased dCTP pools ...

2014
Hyun-Ju Kim JungMin Hong Hye-Jin Yoon Young-Ran Yoon Shin-Yoon Kim

Osteoclasts are large polykaryons that have the unique capacity to degrade bone and are generated by the differentiation of myeloid lineage progenitors. To identify the genes involved in osteoclast development, we performed microarray analysis, and we found that carboxypeptidase E (CPE), a prohormone processing enzyme, was highly upregulated in osteoclasts compared with their precursors, bone m...

Journal: :Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2011
T D Huang P Bogaerts C Berhin B Jans A Deplano O Denis Y Glupczynski

We report on the evolution and epidemiology of carbapenem non-susceptible Enterobacteriaceae (CNSE) including carbapenemase-producing Enterobacteriaceae (CPE) in Belgium between January 2007 and April 2011. Significantly higher numbers of CNSE and of CPE were detected in 2010 and 2011 compared to the years 2007 to 2009. The majority of patients carrying CPE did not have history of travel abroad...

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