Efficient intracellular drug delivery and target specificity are often hampered by the presence of biological barriers. Thus, compounds that efficiently cross cell membranes are the key to improving the therapeutic value and on-target specificity of non-permeable drugs. The discovery of cell-penetrating peptides (CPPs) and the early design approaches through mimicking the natural penetration do...

Chronic prostatitis or chronic pelvic pain syndrome (CP/CPPS) is a versatile, clinical condition, which poses challenges for both patients and clinicians. The aim of this review is to survey the literature for recent developments in the etiology, diagnosis and treatment of CP/CPPS. There are many theories regarding the development of CP/CPPS but they require further investigation. To check for ...

With the development of informatization and intellectualization technology, power system has become cyber-physical (CPPS) with deep integration cyber side physical side. As support smart grids new forms features, CPPS considers coupling relationship between communication network grid, is a research hotspot in field grids. This paper provides an overview framework describes interaction grid. The...

A small library of cell-penetrating peptides (CPPs) containing a minimized cationic domain and a lipophilic domain of different size was studied. CPPs that could self-assemble were found to enter cells more efficiently, triggering a glycosaminoglycan-dependent pathway.

OBJECTIVE Choroid plexus papillomas (CPPs) are generally regarded as benign tumors with typical radiologic and pathologic findings. However, they sometimes have unusual findings. We have analyzed radiologic findings and pathologic growth patterns on CPPs. METHODS The study group included 5 male and 5 female patients (age range, 3 months to 58 years : median, 29 years). The study group include...

In the last 13 years several synthetic strategies were developed that provide access to [n]cycloparaphenylenes ([n]CPPs) and related conjugated nanohoops. A number of potential applications emerged, including optoelectronic devices, their use as templates for carbon nanomaterials in supramolecular chemistry. To tune structural or properties nanohoops beyond size-dependent effect known [n]CPPs, ...

Nanomaterials have been utilized in biomedical applications for many years because of their unique properties such as quantum confinement, surface plasmon resonance, and superparamagnetism. These applications are expected to advance diagnosis and therapeutics. Fluorescent nanomaterials, such as quantum dots (QDs), were exalted in biological imaging and tracking, and trended to replace protein-b...

The cell membrane is a highly selective barrier. This limits the cellular uptake of molecules including DNA, oligonucleotides, peptides and proteins used as therapeutic agents. Different approaches have been employed to increase the membrane permeability and intracellular delivery of these therapeutic molecules. One such approach is the use of Cell Penetrating Peptides (CPPs). CPPs represent a ...

Chronic prostatitis (CP) refers to "inflammation" of the prostate and is thought to be related to either an acute or chronic infection of the prostate gland. It is important to distinguish chronic prostatitis / chronic pelvic pain syndrome (CPPS) from other forms of infections of the prostate gland which include chronic bacterial prostatitis and acute bacterial prostatitis [1]. The aetiology, p...

Smart grid technologies are based on the integration of cyber network and power into a cyber-physical system (CPPS). The increasing interdependencies bring about tremendous opportunities for modeling, monitoring, control, protection grids, but also create new types vulnerabilities failure mechanisms threatening reliability resiliency operation. A major concern regarding interdependent networks ...