Objective: This study was conducted to evaluate effects of guanidinoacetic acid and creatine supplementation in the presence or absence supplemental betaine on lean tissue growth growing cattle.

Dietary creatine supplementation is associated with increases in muscle mass, but the mechanism is unknown. We tested the hypothesis that creatine supplementation enhanced myofibrillar protein synthesis (MPS) and diminished muscle protein breakdown (MPB) in the fed state. Six healthy men (26 +/- 7 yr, body mass index 22 +/- 4 kg/m(2)) were studied twice, 2-4 wk apart, before and after ingestion...

BACKGROUND Use of creatine has become widespread among sportsmen and women, although there are no conclusive evidences concerning possible health risks of long-term creatine supplementation. THE AIM OF THE STUDY To investigate long-term effects of creatine monohydrate supplementation on clinical parameters related to health. METHODS Eighteen professional basketball players of the first Span...

Background The improvement in anaerobic exercise capacity associated with supplementation with creatine monohydrate (CrM) has been well established. Extracts of Russian Tarragon (RT) have been reported to produce antihyperglycemic effects [1] and influence plasma creatine levels during the ingestion of CrM [2]. Theoretically, RT ingestion may enhance creatine retention and thereby promote great...

M ultidisciplinary pulmonary rehabilitation now has an established place in the management of chronic disabling respiratory diseases, particularly chronic obstructive pulmonary disease (COPD). Rehabilitation is being taken up widely on the strength of the accumulated evidence. While the effectiveness of rehabilitation is accepted, there is still considerable interest in refining and researching...

Creatine (Cr) has been shown to increase the total muscle mass. The purpose of this study was to investigate the effect of Cr supplementation on muscle morphology and swimming performance, using an animal model. Each rat was subjected to exercise 15-minute period daily for the 12 weeks. The rats were randomly divided into four groups: no Cr supplementation (CON), no Cr supplementation and incom...

BACKGROUND Chronic supplementation with creatine monohydrate has been shown to promote increases in total intramuscular creatine, phosphocreatine, skeletal muscle mass, lean body mass and muscle fiber size. Furthermore, there is robust evidence that muscular strength and power will also increase after supplementing with creatine. However, it is not known if the timing of creatine supplementatio...

The creatine/phosphocreatine pathway plays a conserved and central role in energy metabolism. Compartmentalization of specific creatine kinase enzymes permits buffering of local high energy phosphates in a thermodynamically favorable manner, enabling both rapid energy storage and energy transfer within the cell. Augmentation of this metabolic pathway by nutritional creatine supplementation has ...