Crohn disease is a chronic inflammatory bowel disease of unknown etiology. Mycobacterium avium paratuberculosis (MAP) was found in the gut of patients with Crohn disease, but causality was not established. Fully developed, germ-free human small intestine and colon were established by subcutaneous transplantation of fetal gut into SCID (severe combined immunodeficiency) mice thereafter infected ...

Crohn disease often recurs after surgical resection. Despite extensive research in the prevention of postoperative Crohn disease, optimal management strategies have yet to be defined. Risk of disease recurrence needs to be carefully balanced against potential risks associated with treatment. Patients with low risk of postoperative recurrence may not require medication, whereas those at moderate...

Inflammatory bowel disease is a chronic inflammatory condition of the gastrointestinal tract that manifests as ulcerative colitis and Crohn disease. Both these clinical entities result from interrelated genetic and environmental factors that may be channeled through an abnormality in mucosal immune function, possibly due to dysregulated or excessive T helper cell (T(H))1 (Crohn disease) or T(H)...

Definition Typical presentation of Crohn disease includes inflammation in the terminal ileum. However, this typical presentation with ileitis is seen only in 70% of cases. 25% of patients present with disease confined only to the colon (Crohn colitis) and in 5% exclusive involvement of the upper gastrointestinal tract is seen. The diagnosis is mostly based on a suggestive clinical course, a typ...

Crohn’s disease is a chronic inflammatory condition that can affect any segment of the gastrointestinal tract from the oral cavity to the anus. The disease often manifests with varied symptoms and numerous potential complications that include intestinal strictures, enteric fistulas, intaabdominal abscesses, and gastrointestinal hemorrhage. Patients with Crohn’s disease are a heterogeneous group...

Background: Crohn’s disease is an inflammatory bowel disease that can affect any part of the gastrointestinal (GI) tract including the mouth. Bowel symptoms are predominant. Oral involvement may precede the GI symptoms. This case report presents a patient affected by Crohn’s disease with oral onset. Case presentation: We present a 30-year-old pregnant woman complaining of chronic, ...

La enfermedad de Crohn es una afección crónica inflamatoria del tracto gastrointestinal que puede afectar cualquier parte sistema digestivo, desde la boca hasta el ano. patogenia involucra combinación factores genéticos, ambientales e inmunológicos conducen a inflamación y daño en tejido intestinal. Los síntomas pueden variar incluir dolor abdominal, diarrea, pérdida peso fatiga. El diagnóstico...

Epstein-Barr virus (EBV) plays an important role in various diseases. EBV-associated lymphoproliferative disease (LPD) is a rare disease with a canceration tendency. It is difficult to differentiate LPD with involvement of digestive tract from Crohn disease due to similar clinical and endoscopic manifestations. We present a case report of multiple ulcers with esophagus, small bowel and the enti...