Streptococcus pneumoniae accounts for more deaths worldwide than any other single pathogen through diverse disease manifestations including pneumonia, sepsis and meningitis. Life-threatening acute cardiac complications are more common in pneumococcal infection compared to other bacterial infections. Distinctively, these arise despite effective antibiotic therapy. Here, we describe a novel mecha...

The scope of this study is to relate the acoustic activity of damage in composites to the failure mechanisms associated with these materials. Cross ply fiber reinforced composites were subjected to tensile loading with recording of their acoustic activity. Acoustic emission (AE) parameters were employed to monitor the transition of the damage mechanism from transverse cracking (mode I) to delam...

Structure– phenomenological hereditary model for prediction of viscoelastic properties of layered polymer composites based on hereditary mechanics and theory of laminated plates relationships was elaborated. Interrelated creep and relaxation constitutive equations of layered composite was derived on the basis of algebra of resolvent operators and matrix algorithms. On example of cross-ply carbo...

In this paper, the effects of stacking sequence and ply orientation on mechanical properties pineapple leaf fibre (PALF)/carbon hybrid laminate composites were investigated. The laminates fabricated using a vacuum infusion technique in which sequences orientations varied, divided into categories cross-ply symmetric, angle-ply symmetric quasi-isotropic. results tensile flexural tests showed that...

Streptococcus pneumoniae is the causative agent of multiple diseases, including otitis media, pneumonia, bacteremia, and meningitis. Pneumolysin (Ply), a member of the cholesterol-dependent cytolytic pore-forming toxins, is produced by virtually all clinical isolates of S. pneumoniae, and strains in which the Ply gene has been deleted are severely attenuated in mouse models of infection. In con...

We consider the recently introduced model of low ply graph drawing, a straight-line drawing in which the ply-disks of the vertices do not have many common overlaps, which results in a good distribution of the vertices in the plane. The ply-disk of a vertex is the disk centered at it whose radius is half the length of its longest incident edge. We focus our attention on low-ply drawings of trees...

This paper is the second of a two-part series assessing the feasibility of using the J-integral with full-field deformation data from Digital Image Correlation (DIC) to characterize toughness in continuous fiber, SiCf/SiCc ceramic matrix composites (CMCs). In Part I, line and area integral adaptations of the J-integral were validated with analytical and experimental deformation fields. It was f...

The cholesterol-dependent cytolysin (CDC) pneumolysin (Ply) is a key virulence factor of Streptococcus pneumoniae. Membrane cholesterol is required for the cytolytic activity of this toxin, but it is not clear whether cholesterol is the only cellular receptor. Analysis of Ply binding to a glycan microarray revealed that Ply has lectin activity and binds glycans, including the Lewis histo-blood ...