Abstract It is unknown whether dysregulated CSF1R himonocytes/macrophages drive the progression to diabetes and if their removal endogenous replacement with fresh macrophages resolves disease. Therefore, we hypothesize that depletion of activated CSF1R+ tissue using a monoclonal antibody against freshly differentiated will alleviate inflammation in tissues ameliorate diabetes-associated disease...

Interactions between mammary epithelial and mesenchymal cells including fibroblasts and adipocytes are crucial for the proper postnatal development of the mammary ductal tree. Often overlooked, however, are the migrant cells that enter tissues at different stages of development. In this paper we identify two such cell types, macrophages and eosinophils, that are recruited around the growing ter...

To characterize the molecular phenotype of spermatogonial stem cells (SSCs), we examined genes that are differentially expressed in the stem/progenitor spermatogonia compared to nonstem spermatogonia. We isolated type A spermatogonia (stem and nonstem type A) from 6-day-old mice using sedimentation velocity at unit gravity and further selected the stem/progenitor cell subpopulation by magnetic ...

Listeria monocytogenes, a facultative intracellular bacterium, has been used extensively to study innate immune responses. Macrophages act as hosts for this bacterium as well as a major defense against it. Using mice homozygous for a null mutation (Csf1(op)) in the gene for the mononuclear phagocytic growth factor colony-stimulating factor 1 (CSF-1), we have demonstrated that CSF-1-regulated ma...

CONTEXT Macrophage infiltration into adipose tissue has been demonstrated to accompany obesity, with a potential preferential infiltration into intraabdominal vs. sc fat. OBJECTIVE Our objective was to determine whether this occurs across different populations with a range of body mass indexes and to assess the relationship with regional adiposity and comorbidity of obesity. SETTING AND PAT...

Abstract Introduction As part of surgical reconstruction with autologous fat grafting, ADSCs are believed to play a pivotal role in the observed anti-fibrotic effect, however, exact mechanisms remain unknown. Here, we explored changes ADSC secretome after proinflammatory and profibrotic stimulation in-vitro gain further mechanistic insights. Methods were obtained from five non-obese patients (B...

A recent evaluation of the accuracy of the National Physical Laboratory (NPL) primary frequency standard NPL-CsF1 by K Szymaniec et al (2005 Metrologia 42 49–57) reported an overall frequency uncertainty of δν/ν0 = 1 × 10−15. This stated uncertainty includes a correction of a frequency bias of δν/ν0 = 8 × 10−16 ± 3 × 10−16 attributed by the authors to microwave leakage. We believe that the stat...