This study explores changes in the bone homeostasis by testing N-terminal collagen type I extension propeptide (PINP) marker for osteo-formation and carboxy-terminal region of (CTX-I) osteo-resorption patients taking tocilizumab polymyalgia rheumatica (PMR). Twenty were included prospective open-label TENOR (Clinicaltrials.gov NCT01713842) received three monthly infusions, followed corticostero...

  Objective(s): Recent investigations show that both proliferation and secretion of macromolecules by cells can be regulated by low level laser therapy (LLLT). The aim of this study was to determine whether LLLT could induce a bio-stimulatory effects on human gingival fibroblasts (HGF3-PI 53). Therefore, the effect of laser irradiation on human gingival cell proliferation and collage...

117 postmenopausal women were divided into Normal, Bone loss (BL), and Osteoporosis group. Compared with Normal group (120.96 ± 43.18 μg/L), the serum ferritin (Fer) in BL (223.37 ± 130.27 μg/L) and Osteoporosis group (307.50 ± 161.48 μg/L) was significantly increased (p < 0.05). Fer level was negatively correlated with BMD (p < 0.01). TRACP levels in Osteoporosis group (4.37 ± 1.69 U/L) were s...

PURPOSE Most metabolic bone diseases are characterized by a disturbances in bone resorption, therefore biochemical markers concerning this process are of special interest. Recently, the novel cytokine osteoprotegerin (OPG), belonging to the tumor necrosis factor receptor family has been established as an endogenous inhibitor of osteoclastogenesis and resorption process. In addition serum C-telo...

OBJECTIVE To investigate the relation between biochemical markers of bone, cartilage, and synovial remodelling and the structural progression of knee osteoarthritis. METHODS 62 patients of both sexes with knee osteoarthritis were followed prospectively for one year. From magnetic resonance imaging (MRI), done at baseline and after one year, the volume and thickness of cartilage of the femur, ...

background: th e eff ects of chronic valproic acid administration on bone health have been a matter of concern and controversy.in this study, the bone status following valproate intake was assessed by using several bone-related biochemical markers. materials and methods: in this case-control study, 62 epileptic patients and 40 age- and gender-matched controls were enrolled. the patients had bee...

background: collagen, the most abundant protein in the human body, and as an extracellular matrix protein, has an important role in the fiber formation. this feature of the collagen renders  establishment of the structural skeleton in tissues. regarding specific features associated with the collagen, such as, formation of the porous structure, permeability and hydrophilicity, it can also be use...

Weight loss contributes to an increased risk of hip fracture, especially in postmenopausal women. Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation could diminish the adverse effect weight on bone health. The aim this randomized, placebo-controlled, double-blind parallel trial was investigate caloric restriction and n-3 PUFA supplement intake osteogenic markers (carboxylated osteoca...

Osteoarthritis (OA) substantially reduces the quality of life elderly. OA therapy remains a challenge since no treatment options for its causes are so far available. Over recent years, researchers have speculated that emodin may represent potential strategy OA. However, it unclear whether mechanism action is associated with inhibition OA-induced oxidative stress. In present study, antioxidant a...