نتایج جستجو برای: ctrp 12

تعداد نتایج: 580833  

Journal: :International journal of clinical and experimental pathology 2014
Shaohui Lin Shaojun Ma Ping Lu Wenwei Cai Yi Chen Jing Sheng

CTRP3, discovered as novel adipokines, is a member of the C1q tumor necrosis factor (TNF) related protein (CTRP) super-family. CTRP3 is found to function as adipokines that display diverse biological activities in metabolic and cardiovascular diseases. Recent study demonstrated that CTRP3 was protective against pathological cardiac remodeling in mice. Nevertheless, the effect of CTRP3 on vascul...

2014
Daisuke Yuasa Koji Ohashi Rei Shibata Kyosuke Takeshita Ryosuke Kikuchi Ryotaro Takahashi Yoshiyuki Kataoka Megumi Miyabe Yusuke Joki Takahiro Kambara Yusuke Uemura Kazuhiro Matsuo Satoko Hayakawa Mizuho Hiramatsu-Ito Masanori Ito Nobuo Ikeda Toyoaki Murohara Noriyuki Ouchi

OBJECTIVE Obesity is a major risk factor for cardiovascular disease. Recent evidence demonstrates that dysregulation of fat-derived hormones, also known as adipokines, is linked with the pathogenesis of obesity-related disorders including coronary artery disease (CAD). Here, we investigated whether circulating level of an adipokine C1q/TNF-related protein (CTRP) 1 is associated with the prevale...

Journal: :Plastic and Reconstructive Surgery - Global Open 2019

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008
Jun Ho Jeon Kun-yong Kim Jae Hyeong Kim Ahmi Baek Hyungin Cho Young Ho Lee Jong Wan Kim Dohee Kim Seung Hyun Han Jong-Seok Lim Keun Il Kim Do Young Yoon Soo-Hyun Kim Goo Taeg Oh Eunjoon Kim Young Yang

Complement-C1q TNF-related protein 1 (CTRP1), a member of the CTRP superfamily, is expressed at high levels in adipose tissues of obese Zucker diabetic fatty (fa/fa) rats, and CTRP1 expression is induced by proinflammatory cytokines, including TNF-alpha and IL-1beta. In the present study, we investigated stimulation of aldosterone production by CTRP1, since it was observed that CTRP1 was specif...

Journal: :Molecular and Cellular Endocrinology 2015
Tae Woo Jung Ho Cheol Hong Hwan-Jin Hwang Hye Jin Yoo Sei Hyun Baik Kyung Mook Choi

C1q/TNF-Related Protein (CTRP) 9, the closest paralog of adiponectin, has been reported to protect against diet-induced obesity and non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanism has not been fully elucidated. We explored the protective effect of CTRP9 against hepatic steatosis and apoptosis, and identified the mechanisms through autophagy and endoplasmic reticulum...

Journal: :Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 2010
Marek Svestak Lenka Sporova Pavel Hejduk Borek Lacnak David Stejskal

BACKGROUND Increasing evidence from numerous research studies in internal medicine shows that adipocytes and adipokines are involved in primary inflammatory processes and disease. CORS-26 (collagenous repeat- containing sequence of 26 kDa protein) is a newly discovered adipokine of the C1q/TNF molecular superfamily C1q/TNF-related protein-3 (CTRP-3) secreted, inter alia in murine monocytes and ...

2014
Xuebo Pan Tingting Lu Fan Wu Leigang Jin Yi Zhang Lihua Shi Xiaokun Li Zhuofeng Lin

BACKGROUND Complement-C1q TNF-related protein 1 (CTRP1), a member of the CTRP superfamily, possesses anti-inflammatory and anti-diabetic effects in mice. However, the clinical relevance of CTRP1 has been seldom explored. The current study aimed to investigate the association of circulating CTRP1 and type 2 diabetes mellitus (T2DM) in a Chinese population. DESIGN AND METHODS Serum CTRP1 and ad...

Journal: :The Journal of Experimental Medicine 1999
Masao Yuda Hiroshi Sakaida Yasuo Chinzei

CTRP (circumsporozoite protein and thrombospondin-related adhesive protein [TRAP]-related protein) of the rodent malaria parasite Plasmodium berghei (PbCTRP) makes up a protein family together with other apicomplexan proteins that are specifically expressed in the host-invasive stage 1. PbCTRP is produced in the mosquito-invasive, or ookinete, stage and is a protein candidate for a role in ooki...

2017
Bo Bai Bo Ban Zunjing Liu Man Man Zhang Bee Kang Tan Jing Chen

OBJECTIVES The C1q complement/TNF-related protein (CTRP) superfamily, which includes the adipokine adiponectin, has been shown in animal models to have positive metabolic and cardiovascular effects. We sought to investigate circulating CTRP1, CTRP9, CTRP12 and CTRP13 concentrations in persons with type 2 diabetes mellitus (T2DM), with age and BMI matched controls, and to examine the effects of ...

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