We propose a novel approach to model serially dependent positive-valued variables which realize a non-trivial proportion of zero outcomes. This is a typical phenomenon in financial time series observed at high frequencies, such as cumulated trading volumes. We introduce a flexible point-mass mixture distribution and develop a semiparametric specification test explicitly tailored for such distri...

The study of cumulated jnd scales began with Fechner; Fechner's law is such a scale. Psychophysicists have been deriving such scales and comparing them with scales derived in other ways, notably by fractionation, ever since, and a lot of controversy has resulted. The controversy is particularly hot at present because Stevens and Galanter (16) and Stevens (14) have assembled a lot of data which ...

PET/CT imaging allows for image based estimates of organ and red marrow (RM) residence times. The aim of this study was to derive PET/CT based radiation dosimetry for Zr-cetuximab, with special emphasis on determining RM absorbed dose. Methods: Seven patients with colorectal cancer received 36.9 ± 0.8 MBq Zr-cetuximab within 2 h after administration of a therapeutic dose of 500 mg⋅m of cetuxima...

background: radioiodine therapy has proven to be an effective method in the treatment of patients with differentiated thyroid carcinoma after thyroidectomy. the scope of this study is to describe a method to obtain the dose of organs using medical internal radiation dosimetry (mird) method. at the end, the results of mird calculations were compared with thermoluminescent dosimeter (tld-100). ma...

Markov models are the most used tools when analyzing complex systems from the performance, dependability or performability points of view. They can capture most of the important aspects of the systems, at the price however of a possible combinatorial explosion in the number of states of the models. In such a case, the many available numerical methods are often of no use, and one of the possible...

Measuring is a key to scientific progress. This is particularly true for research concerning complex systems. Multilingual and multimedia information access systems, such as search engines, are increasingly complex: they need to satisfy diverse user needs and support challenging tasks. Their development calls for proper evaluation methodologies to ensure that they meet the expected user require...

IR research has a strong tradition of laboratory evaluation of systems. Such research is based on test collections, pre-defined test topics, and standard evaluation metrics. While recent research has emphasized the user viewpoint by proposing user-based metrics and non-binary relevance assessments, the methods are insufficient for truly user-based evaluation. The common assumption of a single q...