Abstract Oral squamous cell carcinoma (OSCC) is a malignant tumour of Head and Neck Cancer (HNC). The recent therapeutic approaches used to treat cancer have adverse side effects. natural agents exhibiting anticancer activities are generally considered robust potential. Curcuminoids, one the major active compounds turmeric herb, as agent for several diseases including cancer. In this study, cyt...

turmeric is an important herb used as medicines, turmeric is an important herb used as medicine, condiment and cosmetic. its main active compounds are curcuminoids and essential oils. the biomass production, essential oil composition and curcuminoid content of curcuma longa are known to be dependent on the growth and development conditions of rhizome. iran is a major importer of turmeric in the...

The spice turmeric has been used for centuries not only to flavor, color, and preserve foods but also as a medicinal remedy, and it has been used for thousands of years in Ayurvedic medicine for the treatment of inflammatory disorders. Turmeric is derived from the plant Curcuma longa, a member of the ginger family, and its rhizome (root) is the most useful part for culinary and medicinal purpos...

Study was undertaken to evaluate the neurodegenerative defending potential of curcumin (CUR), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) on 6-hydroxydopamine-(6-OHDA) induced Parkinsonism model in rats. Curcuminoids were administered (60 mg/kg, body weight, per oral) for three weeks followed by unilateral injection of 6-OHDA on 22nd day (10 μg/2 μL) into the right striatum leading...

We aimed to compare the anti-inflammatory activities of six species of Curcuma drugs using adjuvant arthritis model mice. When orally administered 1 day before the injection of adjuvant, the methanol extract of Curcuma phaeocaulis significantly inhibited paw swelling and the serum haptoglobin concentration in adjuvant arthritis mice. Also when orally administered 1 day after the injection of ad...

Curcuminoids are a safe natural food coloring additive with anti-inflammatory, antioxidant, and anticarcinogenic activities. Although demethoxycurcumin is one of the major bioactive constituents of curcuminoids, knowledge about its metabolic fate is scant. In the present study, four new metabolites, 5-dehydroxy-hexahydro-demethoxycurcumin-A (M-1), 5-dehydroxy-hexahydro-demethoxycurcumin-B (M-2)...

In search of better NSAIDs four novel nitric oxide donating derivatives of curcumin (compounds 9a-d), and four thiophene curcuminoids (compounds 10a-c, 11) have been synthesised. The cytotoxic effects of these compounds along with the lead compound curcumin (7) and their effect on the production of the reactive oxygen species nitric oxide and pro-inflammatory cytokines IL-1β, TNF-α and chemokin...

The phytochemical curcumin may improve translocation of the cystic fibrosis transmembrane regulatory (CFTR) protein in lung epithelium and therefore be helpful in the treatment of cystic fibrosis (CF) symptoms. However, previous studies often use commercial curcumin that is a combination of curcumin, demethoxycurcumin and bisdemethoxycurcumin which could affect the investigated cells differentl...

Turmeric is an important spice crop with documented human health benefits associated with chemicals called curcuminoids. In this study, the termite Reticulitermes flavipes (Kollar) was exposed to different solvent extracts of turmeric to investigate potential termiticidal properties. Treating termites with hexane extracts of purified lab-grade curcuminoids had no effect on termites. However, in...

India has rich history of using plants for medicinal purposes. Curcuma species are well-known indigenous medicine. They are used for the treatment of various ailments and metabolic disorders. In Manipur, traditionally the rhizomes of Curcuma caesia Roxb. is used in treating leucoderma, asthma, tumours, piles, bronchitis etc. The paste is applied on bruises, contusions and rheumatic pains. Essen...