Address correspondence to: Di Xia, Laboratory of Cell Biology, National Cancer Institute, NIH, 37 Convent Dr., Building 37, Room 2122C, Bethesda, MD 20892, USA, Tel: (301) 435-6315; Fax: (301) 480-2315; Email: [email protected]; or Stephen J. Savarino, U.S. Naval Medical Research Center, 503 Robert Grant Ave, Silver Spring, MD 20910, USA, Tel: (301) 319-7650; Fax: (301) 319-7679; Email: savar...

PURPOSE Tumor-specific replication-selective oncolytic virotherapy is a promising antitumor therapy for induction of cell death in tumor cells but not of normal cells. We previously developed an oncolytic adenovirus, OBP-301, that kills human epithelial malignant cells in a telomerase-dependent manner. Recent evidence suggests that nonepithelial malignant cells, which have low telomerase activi...

Monoclonal antibody Cat-301 recognizes a surface antigen on subsets of neurons in many areas of the mammalian CNS, including Y-cells in the cat dorsal lateral geniculate nucleus (LGN) and spinal motor neurons in several species. We have shown previously that the Cat-301 antigen is expressed relatively late in postnatal development, with a time course that matches that of late developmental feat...

Tumor suppressor p53 is a multifunctional transcription factor that regulates diverse cell fates, including apoptosis and autophagy in tumor biology. p53 overexpression enhances the antitumor activity of oncolytic adenoviruses; however, the molecular mechanism of this occurrence remains unclear. We previously developed a tumor-specific replication-competent oncolytic adenovirus, OBP-301, that k...

Integrated Ocean Drilling Program Expedition 301 was part of a long term series of operations and experiments focused on quantifying hydrogeologic, lithologic, biogeochemical, and microbiological properties, processes, and linkages in basaltic crust on the eastern flank of the Juan de Fuca Ridge. This paper summarizes peer-reviewed hydrogeologic studies published since the end of Expedition 301...

Aedes aegypti (= Stegomyia aegypti) mosquito is a world vector of important arboviral diseases like dengue and Rift Valley fever. Despite its wide distribution in the western and southern regions of Saudi Arabia, where dengue outbreaks have occurred, its ecology is largely unknown. In this study we report on the main life table developmental attributes of a laboratory colony of Ae. aegypti rear...

This course is a survey of basic numerical methods and algorithms used for linear algebra, ordinary and partial differential equations, data manipulation and visualization. Emphasis will be on the implementation of numerical schemes to practical problems in the engineering and physical sciences. Full use will be made of MATLAB and its programming functionality. These notes are intended as the p...

The purpose of this study was to determine the efficacy and the possible mechanism of action of a recently synthesized drug, TAS-301 [3-bis (4-methoxyphenyl)methylene-2-indolinone], on intimal formation in comparison with those of tranilast, the clinical efficacy of which was reported earlier. Rat carotid arteries were injured using a balloon catheter. Neointimal thickening, measured 14 days af...

Osteosarcoma is an aggressive malignant bone tumor that causes bone destruction. Although tumor-specific replicating oncolytic adenovirus OBP-301 induces an antitumor effect in an osteosarcoma tumor, it cannot prevent bone destruction. Zoledronic acid (ZOL) is a clinically available agent that inhibits bone destruction. In this study, we investigated the potential of combination therapy with OB...