The α2β1 antagonist rhodocetin from Calloselasma rhodostoma is a heterotetrameric CLRP (C-type lectin-related protein) consisting of four distinct chains, α, β, γ and δ. Via their characteristic domain-swapping loops, the individual chains form two subunits, αβ and γδ. To distinguish the four chains which share similar molecular masses and high sequence homologies, we generated 11 mAbs (monoclo...

In this article, we introduce a new concept of admissible contraction and prove fixed point theorems which generalize Banach principle in different way more than the known results from literature. The article includes an example shows validity our results, additionally obtain solution integral equation by mapping setting b-metric spaces.

Abstract Introduction High cognitive arousal—i.e., heightened activity often in the form of perseverative thinking—is a central feature insomnia. Emerging evidence from randomized controlled trials (RCTs) support alleviating arousal as mechanism by which behavioral therapy for insomnia (CBTI) reduces symptoms and depression. However, few RCTs have published CBTI data on outcomes. The present st...

In this paper, we provide some generalizations of the Darbo's fixed point theorem and further develop notion $F$-contraction introduced by Wardowski in (\cite{wad}, D. Wardowski, \emph{Fixed points a new type contractive mappings complete metric spaces,} Fixed Point Theory Appl., 94, (2012)). To achieve this, introduce Darbo-type $F$-contraction, cyclic $(\alpha,\beta)$-admissible operator also...

Emerging data indicate that particular major histocompatibility complex (MHC)-bound antigenic peptides can be recognized by identical or near-identical αβ T cell receptors (TCRs) in different individuals. To establish the functional relevance of this phenomenon, we artificially paired α and β chains from closely related TCRs specific for the human leucocyte antigen (HLA)-B*35:01-restricted HIV-...

In Drosophila, anatomically discrete dopamine neurons that innervate distinct zones of the mushroom body (MB) assign opposing valence to odors during olfactory learning. Subsets of MB neurons have temporally unique roles in memory processing, but valence-related organization has not been demonstrated. We functionally subdivided the αβ neurons, revealing a value-specific role for the ∼160 αβ cor...

In this work, we establish new fixed point theorems for generalized Pata–Suzuki type contraction via α -admissible mapping in metric spaces and to prove some results such mappings. Moreover, give an example illustrate our main result. Consequently, the presented paper generalize improve corresponding of literature.

We prove the rigid phase conjecture of Stewart and Parker. It then follows from previous results (of Stewart and Parker and our own) that rigid phase-shifts in periodic solutions on a transitive network are produced by a cyclic symmetry on a quotient network. More precisely, let X(t) = (x1(t), . . . , xn(t)) be a hyperbolic T -periodic solution of an admissible system on an n-node network. Two ...

In the thymus, hematopoietic progenitors commit to the T cell lineage and undergo sequential differentiation to generate diverse T cell subsets, including major histocompatibility complex (MHC)-restricted αβ T cell receptor (TCR) T cells and non-MHC-restricted γδ TCR T cells. The factors controlling precursor commitment and their subsequent maturation and specification into αβ TCR versus γδ TCR...