Incubation at approximately physiological conditions of amino acids, peptides, and proteins with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea or cyclohexyl isocyanate resulted in carbamoylation of the alpha-amino groups of amino acids, the terminal amino groups of peptides and proteins and the epsilon-amino groups of lysine moieties. Carbamoylation of the alpha-amino groups and the terminal ami...

Changes in the substitutions at C-3 and C-5 positions of 4-(1-methyl-5-nitro-2-imidazolyl) dihydropyridine analogs of nifedipine have led to changes in potency of the compounds. The objective of the present study was to examine the hypotensive effects of 5 newly synthesized dihydropyridine derivatives of nifedipine in rats with phenylephrine-raised blood pressure. Anesthetized Sprague-Dawley ra...

Background and Objective: Regarding the prevalence of epilepsy in human society and with respect to insufficiency of usual treatments, new strategies and methods for medical treatment of epileptic patients are necessary. As NMDA receptor antagonists are the most prominent anti-epileptic drugs, in the present study, we synthesized and investigated anti-epileptic effect of a new piperidine deriva...

Somenewtriethylammoniumsalts,namelytriethylammonium4-(cyclohexyl-amino)-4-oxobut-2-enoate(B1),triethylammonium5-(cyclohexylamino)-5-oxopentanoate(B2),triethylammonium4-(cyclohexylamino)-4-oxobutanoate(B3)weresynthesizedasacorrosioninhibitorformildsteel.Thesesaltscouldtestinonemolaritysulfuricacidatroomtemperaturefor24hoursbyusingweightoflosingmethod.Theresultsrevealedthattheefficiencyofinhibiti...