نتایج جستجو برای: cyp2c19 polymorphism

تعداد نتایج: 108891  

Journal: :Biological & pharmaceutical bulletin 2012
Naoki Matsuzawa Katsunori Nakamura Masayuki Matsuda Fumihiro Ishida Shigeru Ohmori

PURPOSE Cytochrome P450 (CYP)2C19 polymorphisms may partly explain the variability of thalidomide concentration and adverse drug effects by altering its metabolism. To compare the genetic and clinical factors responsible for the adverse effects and efficacy of thalidomide treatment, we investigated CYP2C19 genetic polymorphisms in Japanese subjects. MATERIALS AND METHODS Variations in the CYP...

Journal: :Journal of medical economics 2015
Y J Lu G X Xu W Q Lu Z Liu Song Rl J Xuan

OBJECTIVES To evaluate the cost-effectiveness of 10 mg ilaprazole once-daily vs 20 mg omeprazole once-daily to treat newly-diagnosed duodenal ulcer patients in China. METHODS A decision tree model was constructed and the treatment impact was projected up to 1 year. The CYP2C19 polymorphism distribution in the Chinese population, the respective cure rates in the CYP2C19 genotype sub-groups, th...

2013
Pierre Fontana Marco Cattaneo Christophe Combescure Jean‐Luc Reny

Between 20% and 50% of cardiovascular patients treated with clopidogrel, an anti-P2Y12 drug, display high on-treatment platelet reactivity (HTPR) and are not adequately protected from major adverse cardiovascular events (MACE). Despite a minor influence of the CYP2C19*2 genetic variant on the pharmacodynamic response to clopidogrel (5% to 12%) and a limited or absent value for predicting stent ...

2014
Yadong Li Heyin Yang Xiaoguang Zou Lijun Xiong Zhen Li Jianzhang Luo Bo Zhao Wen Liu Xili Du

BACKGROUND The aim of this study was to analyze the CYP2C19 genetic polymorphism among Han and Uyghur patients with cardiovascular and cerebrovascular diseases in the Kashi area of Xinjiang. MATERIAL/METHODS We enrolled 1020 patients with cardiovascular and cerebrovascular diseases, including 220 Han subjects and 800 Uyghur subjects. We used the gene chip method to detect polymorphisms in CYP...

2013
Xiang Xie Yi-Tong Ma Yi-Ning Yang Xiao-Mei Li Xiang Ma Zhen-Yan Fu Ying-Ying Zheng Bang-Dang Chen Fen Liu

BACKGROUND Several studies have indicated that CYP2C19 loss-of-function polymorphisms have a higher risk of stent thrombosis (ST) after percutaneous coronary interventions (PCIs). However, this association has not been investigated thoroughly in a Chinese population. In this study, we aimed to determine the effect of CYP2C19*2 and CYP2C19*3 loss-of-function polymorphisms on the occurrence of ST...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2004
Carole Giraud Agnès Tran Elisabeth Rey Jean Vincent Jean-Marc Tréluyer Gérard Pons

The specific cytochrome P450 (P450) isoforms mediating the biotransformations of clobazam (CLB) and those of its major metabolites, N-desmethylclobazam (NCLB) and 4'-hydroxyclobazam were identified using cDNA-expressed P450 and P450-specific chemical inhibitors. Among the 13 cDNA-expressed P450 isoforms tested, CLB was mainly demethylated by CYP3A4, CYP2C19, and CYP2B6 and 4'-hydroxylated by CY...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2010
Miho Kazui Yumi Nishiya Tomoko Ishizuka Katsunobu Hagihara Nagy A Farid Osamu Okazaki Toshihiko Ikeda Atsushi Kurihara

The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. In the in vitro experiments using cDNA-expressed human P450 isoforms, clopidogrel was metabolized to 2-oxo-clopidogrel, the immediate precursor of its pharmacologically active metabolite. CYP1A2,...

2006
Jean-Sébastien Hulot Alessandra Bura Eric Villard Michel Azizi Véronique Remones Catherine Goyenvalle Martine Aiach Philippe Lechat Pascale Gaussem

The capacity of clopidogrel to inhibit ADPinduced platelet aggregation shows wide intersubjectvariability.Todeterminewhether frequent functional variants of genes coding for candidate cytochrome P450 (CYP) isoenzymes involved in clopidogrel metabolic activation (CYP2C19*2, CYP2B6*5, CYP1A2*1F, and CYP3A5*3 variants) influence the platelet responsiveness to clopidogrel, we conducted a prospectiv...

2017
Amanda J Laska Marie J Han Josh A Lospinoso Patrick J Brown Thomas M Beachkofsky

PURPOSE Genetic polymorphisms have been linked to an increased predisposition to developing certain diseases. For example, patients of Han-Chinese descent carrying the HLA-B*1502 allele are at an increased risk of developing Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) if given carbamazepine. Given the complexity of in vivo drug metabolism, it is plausible that the activity...

Al-Inany H

Infertility is a very disastrous side effect in young females, especially in traditional male-dominated societies. The aim of this talk is to discuss the possible ways for fertility preservation in both man and woman. Another aspect is to how to predict women at threat of premature ovarian failure. It will also illustrate the association of cytochrome P450 (CYP2C19) polymorphism with ovarian to...

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