oxygenator containing 30p~-cytochalasin Band returned to the control oxygenator, and a further influx of glucose determined 4min later. The glucose concentration in both oxygenators was the same. The results (Table 2) show that the inhibition is completely reversed within 4min of perfusing the brain with cytochalasin-free blood. The rapid reversibility of the inhibition is in agreement with stu...

The attachment of particle-bound IgG in a nonphagocytic system stimulates formation of a microfilament-rich, organelle-poor zone in the subjacent cytoplasm of human neutrophils. The attachment site is characterized by ruffling and invagination of the neutrophil membrane. Both IgG attachment and formation of the organelle-poor zone are inhibited by the microfilament inhibitor cytochalasin-B, but...

Cytochalasin B inhibits phytomitogen-induced human lymphocyte proliferation with a Ki of approximately 6 X 10(-6) M. Cytochalasins A, C, D, E, and H are also inhibitory with varying degrees of potency, whereas cytochalasin G and chaetoglobosins A, B, C, E, F, and J are not at concentrations as high as 15 microM. Cytochalasin B also competitively inhibits carrier-mediated equilibrium exchange of...

Cytochalasin B (37 fig per ml) reduces the rate of food vacuole formation, i.e. the rate of phagocytosis, in Tetrahymena pyriformis. Cytochalasin B in this concentration suppresses multiplication rates in a nutrient medium consisting of 2 % proteose peptone, but multiplication is unaffected if this medium is supplemented with glucose and high concentrations of nucleosides. Thus nutrients in hig...

The cytopathic effects of Trichomonas vaginalis treated with inhibitory concentrations of anticytoskeletal compounds (mebendazole, griseofulvin, colchicine, taxol, and cytochalasin B) were studied in mouse CLID fibroblast cultures. The evaluation, at different times, of cell numbers and morphological alterations showed that cytopathic effect was considerably reduced when protozoa were pretreate...