The aim of this research was to analyze the features morphofunctional state left ventricular contractile cardiomyocytes offspring mothers with experimental type 1 diabetes mellitus during neonatal period. Diabetes modeled in sexually mature female rats using streptozotocin. Specific area myocardial stroma and parenchyma, number cardiomyocytes, nuclear-cytoplasmic ratio, content binucleated cell...

In this study, we present 84 transmission electron microscopy (TEM) images of human brainstem tissue from 11 cases late onset Parkinson’s disease (PD). The tissues were fixed, embedded, sectioned, and stained for TEM application. In addition, 14 autopsy specimens 1 case poliomyelitis infection as positive controls 8 other conditions negative controls. the PD there cytoplasmic inclusion b...

Abstract Gene mutations causing cytoplasmic mislocalization of the RNA-binding protein FUS lead to severe forms amyotrophic lateral sclerosis (ALS). Cytoplasmic accumulation is also observed in other diseases, with unknown consequences. Here, we show that drives behavioral abnormalities knock-in mice, including locomotor hyperactivity and alterations social interactions, absence widespread neur...

background: glycowithanolides (withaferin a), is one of the main withanolides active principle isolated from plant withania somnifera and is claimed that it possess the aphrodisiac, sedative, rejuvenate and life prolonging properties. objective: in the present investigation, antioxidant activity of active principles of withania somnifera was tested against d-galactose induced oxidative stress i...

The organization and function of eukaryotic cells rely on the action of many different molecular motor proteins. Cytoplasmic dynein drives the movement of a wide range of cargoes towards the minus ends of microtubules, and these events are needed, not just at the single-cell level, but are vital for correct development. In the present paper, I review recent progress on understanding dynein's me...

A 61-year-old male with chronic cough, paraesthesia of the extremities, and sinusitis presented for acute worsening symptoms despite initial treatment antibiotics prednisone. Emergency department evaluation revealed mild elevated troponin without ECG changes in absence coronary symptoms, but markedly eosinophil count an abnormal chest CT. nuclear stress test basal inferoseptal dyskinesis fixed ...

antineutrophil cytoplasmic autoantibodies (anca) were detected in patients with autoimmune and vascular diseases such as wegener's granulomatosis, polyarteritis nodosa and systemic lupus erythematosus. indirect immunofluorescence (iif) technique was employed to detect these autoantibodies. by this method, two general patterns of anca were seen: a cytoplasmic (canca) and a perinuclear form ...

background: patients with ulcerative colitis (uc) carry autoantibodies such as perinuclear antineutrophil cytoplasmic antibodies (p-anca). objective: the aim of the present study was to evaluate the target antigens for p-anca in iranian patients with uc. methods: p-anca target antigens including elastase, lactoferrin, cathepsin g, myeloproxidase, lysozyme, and bactericidal permeability increasi...