we have previously shown that the proliferative response of t cells to antigenic or mitogenic stimulus decreased with age and that caloric resection (cr) attenuated the age-related decline in proliferation and il-2 expression. because activation-induced apoptosis is known to regulate cell proliferation and eliminate the high number of activated cells during an immune response, it was of interes...

introduction: the purpose of this study was to investigate the relationship between serum levels of interleukin-6 (il-6) and the severity and extent of squamous cell carcinoma (scc) of the larynx based on stage of tumor progression and histological grade.   materials and methods: all patients with a diagnosis of laryngeal cancer who underwent laryngoscopy and biopsy while hospitalized in imam k...

introduction: estradiol is a neuroactive steroid, which is found in several brain areas such as locus coeruleus (lc). estradiol modulates nociception by binding to its receptors and also by allosteric interaction with other membranebound receptors like glutamate and gabaa receptors. lc is involved in noradrenergic descending pain modulation. methods: in order to study the effect of 17β-estradio...

objective(s):valproic acid (vpa), a drug used in the treatment of neurological disorders, has been shown to have cytotoxic effects on cancer cells through different mechanisms. telomerase, a ribonucleoprotein reverse transcriptase, is responsible for elongation of the telomere and is activated in cancers. a relation between telomerase activity and resistance to apoptosis has been established. t...

background cervical cancer is one of the leading causes of cancer-related death in females. human papilloma virus (hpv) is the major risk factor of cervical cancer. objectives the aim of the current study was to explore the frequency and role of 23 different hpvs in patients with cervical cancer. materials and methods overall, 117 formalin-fix and paraffin-embedded (ffpe) tissues from cervical ...

understanding the mechanism of tumor resistance is critical for cancer therapy. in this study, we investigated the effect of carcinoembryonic antigen (cea) overexpression on uv-and 5-fluorouracil (5-fu)-induced apoptosis and autophagy in colorectal cancer cells. we used histone deacetylase (hdac) inhibitor, nab and dna demethylating agent, 5- azacytidine (5-aza) to induce cea expression in ht29...

condensation of glyoxal, formaldehyde and anilines lead to the formation of 2,4,6,8- tetraphenyl and substituted phenyl 2,4,6,8-tetraazabicyclo [3.3.0] octanes. the reactions are sensitive to ph and temperature. ortho derivatives of anilines do not participate in this condensation. x-ray structural determination reveals a cis-dienvelope geometery about the two fused rings.

abstract   background: cosmetic rhinoplasty is now carried out increasingly in an attempt to solve the psychological and social problems of people who are discontent with their nose. little is known about either the psychological status of persons who seek rhinoplasty or potential psychological changes following surgery. the challenge that faces surgeons, is how to identify, before surgical int...

background and purpose: lesson plan is considered a vital component of the teacher training and successful teachers are in variably good planners and thinkers. the present study was conducted to survey the academic staff’s views about lesson plan in shiraz university of medical sciences in 2001. moreover, considering the finding of the study there was an attempt to seek the experts’ views on ho...

liquid-liquid equilibrium data for the (water + lactic acid + 2-ethy-1-hexanol) ternary system in t=298.2k and p=1atm were determined and tie- lines related to equilibrium data has been drawn in the phases diagram . the reliability of the experimental tie-line data for this system was as confirmed by using the hand and othmer –tobias correlations. the tie-line data were correlated by means of t...