Hypoxia-inducible factor (HIF)-1α is a key regulator associated with tumorigenesis, angiogenesis, and metastasis. HIF-1α regulation under hypoxia has been highlighted as a promising therapeutic target in angiogenesis-related diseases. Here, we demonstrate that diacetyl atractylodiol (DAA) from Atractylodes japonica (A. japonica) is a potent HIF-1α inhibitor that inhibits the Akt signaling pathw...

Dr. Patrick Netter, URA CNRS 1288, Faculté de Médecine, BP 184, F-54505 Vandœuvre Cedex (France) Dear Sir, We were very interested in the paper of Dr Ozasa [1] relative to plasma levels of hyaluronan (HA) in chronic hemodialysis patients exhibiting characteristic symptoms of dialysis-associated arthropathy (DAA). As it is ubiquitous by nature, HA is not disease specific, but recent studies in j...

OBJECTIVE To examine the nature of disease awareness advertising (DAA). DESIGN Therapeutic advertisements in six popular Australian women's magazines were monitored between April 2006 and March 2007. A subset of advertisements was included in the study based on criteria derived from a definition of DAA. Unique advertisements were analysed by four independent coders. MAIN OUTCOME MEASURES Ty...

Background and aims Short periods of extreme temperature may affect wheat (Triticum aestivum) seed weight, but also quality. Temporal sensitivity to extreme temperature during seed development and maturation was investigated. Methods Plants of 'Tybalt' grown at ambient temperature were moved to growth cabinets at 29/20°C or 34/20°C (2010), or 15/10°C or 34/20°C (2011), for successive 7-d peri...

Purpose The aim of the current study is to report the advantage and disadvantage of total hip arthroplasty performed in direct anterior approach (DAA) by comparing it to the posterolateral approach (PLA). Materials and Methods Twenty-five hip arthroplasty done in DAA (12 total hip arthroplasty [THA] and 13 bipolar hemiarthroplasty [BHA]) were compared with the same number done in PLA (13 THA ...

OBJECTIVE To assess the long-term healthcare costs and health outcomes in association with the access to new direct-acting antivirals (DAAs), during the first year of the National Strategic Plan for Chronic Hepatitis C (SPCHC) in patients with chronic hepatitis C (CHC) in Spain. METHODS A decision tree and a lifetime Markov model were developed to simulate the natural history, morbidity, and ...

Direct Anonymous Attestation (DAA) is an anonymous digital signature scheme that aims to provide both signer authentication and privacy. One of the properties that makes DAA an attractive choice in practice is the split signer role. In short, a principal signer (a Trusted Platform Module (TPM)) signs messages in collaboration with an assistant signer (the Host, a standard computing platform int...

Direct Anonymous Attestation (DAA) is a cryptographic mechanism that enables remote authentication of a Trusted Platform Module (TPM) while preserving its privacy. In this paper, we propose a new DAA scheme based on the strong RSA assumption and the decisional Diffie-Hellman assumption. While satisfying all the security properties proposed in previous DAA schemes, our scheme provides a new desi...

Double aortic arch (DAA) is a form of vascular ring found in approximately 1 in 2000–4000 pregnancies on fetal echocardiography. In some cases of DAA, respiratory compromise occurs during infancy due to compression of the trachea, which is completely encircled by the right aortic arch (RAA) and left aortic arch (LAA). RAA and left arterial duct were initially seen on screening fetal echocardiog...