نتایج جستجو برای: daclizumab

تعداد نتایج: 624  

Journal: :JPMA. The Journal of the Pakistan Medical Association 2005
Tahir Sultan Shamsi Mohammad Irfan Tasneem Farzana Saqib Hussain Ansari Ghazala Ahmad Nazmeen Shakoor Mirza Irfan Baig

The case report of a 2 year old boy with steroid refractory DBA, treated with allogeneic PBSCT from an HLA matched sibling is presented. Anti-IL2 receptor antibody Daclizumab was used as a prophylaxis for graft versus host disease (GvHD). Complete recovery without any evidence of GvHD ensued.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
John E Janik John C Morris Deirdre O'Mahony Stefania Pittaluga Elaine S Jaffe Christophe E Redon William M Bonner Martin W Brechbiel Chang H Paik Millie Whatley Clara Chen Jae-Ho Lee Thomas A Fleisher Maggie Brown Jeffrey D White Donn M Stewart Suzanne Fioravanti Cathryn C Lee Carolyn K Goldman Bonita R Bryant Richard P Junghans Jorge A Carrasquillo Tat'Yana Worthy Erin Corcoran Kevin C Conlon Thomas A Waldmann

Despite significant advances in the treatment of Hodgkin's lymphoma (HL), a significant proportion of patients will not respond or will subsequently relapse. We identified CD25, the IL-2 receptor alpha subunit, as a favorable target for systemic radioimmunotherapy of HL. The scientific basis for the clinical trial was that, although most normal cells with exception of Treg cells do not express ...

2016
Ralf Gold Ernst-Wilhelm Radue Gavin Giovannoni Krzysztof Selmaj Eva Havrdova Dusan Stefoski Till Sprenger Xavier Montalban Stanley Cohan Kimberly Umans Steven J. Greenberg Gulden Ozen Jacob Elkins

BACKGROUND Daclizumab is a humanized monoclonal antibody against CD25 that modulates interleukin 2 signaling. The SELECT TRILOGY of clinical studies (SELECT/SELECTION/SELECTED) evaluated the safety and efficacy of daclizumab in patients with relapsing-remitting multiple sclerosis (RRMS). We report the long-term safety and efficacy of daclizumab 150 mg subcutaneous every 4 weeks in patients with...

Journal: :Molecules 2011
Darko Duplancic Lea Kukoc-Modun Darko Modun Njegomir Radic

Determination of the relative contribution of uric acid level increases to the total measured antioxidative activity could be very useful for testing antioxidative products and their effect on human health. The aim of this report is to present a simple spectrophotometric method that combines the measurement of total antioxidative capacity of a sample by ferric reducing/antioxidative power (FRAP...

Journal: :The New England journal of medicine 2007
Henrik Ekberg Helio Tedesco-Silva Alper Demirbas Stefan Vítko Björn Nashan Alp Gürkan Raimund Margreiter Christian Hugo Josep M Grinyó Ulrich Frei Yves Vanrenterghem Pierre Daloze Philip F Halloran

BACKGROUND Immunosuppressive regimens with the fewest possible toxic effects are desirable for transplant recipients. This study evaluated the efficacy and relative toxic effects of four immunosuppressive regimens. METHODS We randomly assigned 1645 renal-transplant recipients to receive standard-dose cyclosporine, mycophenolate mofetil, and corticosteroids, or daclizumab induction, mycophenol...

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