BACKGROUND Preeclampsia (PE) is a common maternal disease that complicates 5 to 10% of pregnancies and remains as the major cause of maternal and neonatal mortality. Cost-effective interventions aimed at preventing the development of preeclampsia are urgently needed. However, the pathogenesis of PE is not well known. Multiple mechanisms such as oxidative stress, endothelial dysfunction and insu...

OBJECTIVE To assess and compare the efficacy of on-demand versus daily dosages of tadalafil in the treatment of erectile dysfunction. METHODS The case-control double-blind study was conducted at the Department of Urology, Tehran University of Medical Science, Imam Khomeini Hospital, from March 2008 to January 2010. It comprised 100 males suffering from erectile dysfunction who were randomised...

Introduction: According to evidence, Early-Life Stress (ELS), mood disorders, and medical comorbidities, i.e.  Irritable Bowel Syndrome (IBS), are correlated; however, the direct contribution of ELS to IBS manifestations is less understood. The current study aimed at evaluating the effect of voluntary exercise on the mitochondrial dysfunction of the bowel fibroblasts, following the confirmation...

Methods: Retrospective, observational study design. IRB approval was obtained. Inclusion criteria included anticoagulation clinic enrollment, age > 18 years, medication adherence. Exclusion criteria included prior use of TSOAC, renal/liver dysfunction, valvular disease. Oral administration of dabigatran 150 mg twice daily, rivaroxaban 20 mg daily and apixaban 5 mg twice daily were examined. Cop...

OBJECTIVE Vestibular dysfunction increases with age and is associated with mobility difficulties and fall risk in older individuals. We evaluated whether vestibular function influences the ability to perform activities of daily living (ADLs). METHOD We analyzed the 1999 to 2004 National Health and Nutrition Examination Survey of adults aged older than 40 years (N = 5,017). Vestibular function...

The endothelial nitric oxide synthase (eNOS) plays an important homeostatic role in the cardiovascular system (CVS) by maintaining appropriate blood pressure through production of nitric oxide. The 894TT genotype of 894G>T (Glu298Asp, rs1799983), a polymorphic variant of eNOS, has been associated with several vascular diseases. On the basis of this strong relationship, we monitored daily 585 cr...

To evaluate the relevance of transcranial magnetic stimulation (TMS) using triple technique (TST) to assess corticospinal function in amyotrophic lateral sclerosis (ALS) a large-scale multicenter study. Six ALS centers performed TST and conventional TMS upper limbs 98 patients during their first visit center. Clinical evaluation included revised Functional Rating Scale (ALSFRS-R) motor neuron (...

The efficacy of tolterodine was analysed in children with non-neurogenic voiding dysfunction, using dysfunctional voiding symptom score (DVSS). Of 44 patients (mean age 9.3 yrs; M:F = 25:19), 36 received long acting tolterodine tartrate at a dose of 2mg OD and 8 at a dose of 4mg OD. The mean (SD) DVSS before and after the treatment was 17.1 (2.8) and 12.0 (2.4). There was a significant improvem...