KRas4B (henceforth called KRas) is a small GTPase that regulates activation of variety signaling pathways, including the Raf/MEK/ERK pathway, leading to cell proliferation, survival, and differentiation. Activation these pathways dependent on nucleotide-bound state KRas: GTP-bound KRas “turns on” while GDP-bound off” signaling. Interestingly, only one three Ras isoforms interacts with Ca2+-boun...