نتایج جستجو برای: daunorubicin

تعداد نتایج: 2644  

Journal: :Postgraduate Medical Journal 1970

Journal: :The Journal of biological chemistry 1986
K J Davies J H Doroshow

In the present study we have used beef heart submitochondrial preparations (BH-SMP) to demonstrate that a component of mitochondrial Complex I, probably the NADH dehydrogenase flavin, is the mitochondrial site of anthracycline reduction. During forward electron transport, the anthracyclines doxorubicin (Adriamycin) and daunorubicin acted as one-electron acceptors for BH-SMP (i.e. were reduced t...

Journal: :Oncology reports 2011
Nassera Aouali Hassan El Btaouri Charles Dumontet Lahcen Eddabra Sophie Malagarie-Cazenave Claudie Madoulet Hamid Morjani

The selection pressure for resistance to chemotherapy is accompanied by the enhanced expression of ABC proteins and increased cellular glycosphingolipid content. Thus, a possible connection between glycosphingolipid metabolism and ABC proteins in drug resistance has been suggested. In the present study, we established two human multidrug-resistant (MDR) cell lines derived from MESSA sarcoma cel...

2011
Sally-Anne Heasman Lyubov Zaitseva Kristian M. Bowles Stuart A. Rushworth David J. MacEwan

Haem oxygenase-1 (HO-1) is increasingly regarded as a pro-tumoral target in the treatment of human cancers. Currently, little is known about HO-1 and its role in human acute myeloid leukaemia (AML) to regulate apoptosis in response to chemotherapy. Recently, we showed that HO-1 protects AML samples from tumour necrosis factor-α (TNF)-induced apoptosis - it being regulated by transcription facto...

Journal: :Journal of bacteriology 1999
W Bao P J Sheldon E Wendt-Pienkowski C R Hutchinson

The starter unit used in the biosynthesis of daunorubicin is propionyl coenzyme A (CoA) rather than acetyl-CoA, which is used in the production of most of the bacterial aromatic polyketides studied to date. In the daunorubicin biosynthesis gene cluster of Streptomyces peucetius, directly downstream of the genes encoding the beta-ketoacyl:acyl carrier protein synthase subunits, are two genes, dp...

Journal: :Haematologica 1994
M Tolomeo R A Gancitano M Musso F Porretto R Perricone V Abbadessa A Cajozzo

BACKGROUND Many dihydropyridine analogues with calcium channel blocker activity are able to reverse multidrug resistance (MDR). We studied the daunorubicin resistance reversing activity of the R enantiomer (GR66234A) and the L-enantiomer (GR66235 A) of teludipine, a new lipophilic calcium channel blocker synthesized by Glaxo. METHODS The daunorubicin resistance reversing activity of the enant...

Journal: :Blood 1997
S J Hurwitz M Terashima N Mizunuma C A Slapak

The U-A10 cell line, a doxorubicin-selected variant of human U-937 myeloid leukemia cells, exhibits a redistribution of anthracyclines into a expanded vesicular compartment. The acidic nature of this compartment was confirmed by vital staining with a pH sensitive dye, LysoSensor yellow/blue DND-160. Identification of the vesicular compartment was performed by immunofluorescence analysis. Staini...

Journal: :Blood 1984
A J Gottlieb V Weinberg R R Ellison E S Henderson H Terebelo S Rafla J Cuttner R T Silver R W Carey R N Levy

The efficacy of the addition of intensive therapy with daunorubicin (45 mg/m2 IV on days 1, 2, 3) to an otherwise identical induction program consisting of vincristine, prednisone, and L-asparaginase was assessed in 177 previously untreated adults (greater than or equal to 20 years of age) with acute lymphocytic leukemia (ALL). In the prospectively randomized phase of the investigation, 46 pati...

Journal: :Cancer research 1989
P Sweet P K Chan L M Slater

It has recently been shown that anthracycline antibiotic-resistant tumor cells are less responsive to daunorubicin-stimulated B23 nucleolar phosphoprotein translocation than drug-sensitive cells. Since cyclosporin A and verapamil reverse primary acquired and secondary cross-resistance to daunorubicin, we investigated the effect of these agents on nucleolar B23 translocation in sensitive and res...

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