A variety of methods is available to estimate a portfolio’s Value-at-Risk. Aside from the overall VaR there is an apparent need for information about marginal VaR, component VaR and incremental VaR. Expressions for these VaR metrics have been derived under the restrictive normality assumption. In this paper we investigate these VaR concepts in an elliptical world and in a general distribution-f...

Antigenic variation in the human malaria parasite Plasmodium falciparum depends on the transcriptional regulation of the var gene family. In each individual parasite, mRNA is expressed exclusively from 1 var gene out of ∼60, while the rest of the genes are transcriptionally silenced. Both modifications to chromatin structure and DNA regulatory elements associated with each var gene have been im...

background: recent circumstantial evidences are suggesting that an increasing number of iranian patients with cu­taneous leishmaniasis are unresponsive to meglumine antimoniate (glucantime®). pistacia atlantica is native plant in iran (central, western, and eastern regions). gum obtained pistacia atlantica has been reported to possess consid­erable in vitro antimicrobial activity. in this study...

A cluster of 4 cases of meningitis due to Acinetobacter calcoaceticus var anitratus occurred during a 5-day period in a neonatal intensive care unit. Three of the infants were preterm and all had a history of other medical problems. Initiation of intravenous therapy with carbenicillin was accompanied by clinical recovery and a bacteriological cure. Intensive bacteriological investigation failed...

Light-grown 7-day-old wheat seedlings (Triticum aestivum, var. Maris Dove) showed an increase of 200% in plastids per cell between 1.7 and 4.5 centimeters from the leaf base. This increase was the result of divisions of young chloroplasts at various stages of development, and was well separated in distance, and therefore in time from the region of cell division in the basal meristem. [(3)H]Thym...

Cyclopoid copepods and mosquito larvae were surveyed in southwestern Louisiana rice fields. Almost every rice field had a natural population of Mesocyclops ruttneri, Acanthocylops vernalis, or Macrocyclops albidus. Judging from the abundance of pupae, 29% of the fields were responsible for virtually all Anopheles quadrimaculatus production, apparently because larval mortality suppressed product...

After publication of the article [1], it has been brought to our attention that the original version of this Article contained a typo in the 3rd paragraph of the section 'Review process and data extraction'. It concerns the equation published as "Var(lnRR) = Var(lnR1 + lnR0)". On the right part, the "+" within the parenthesis should be "-", as defined and derived from the left part. As a result...

BACKGROUND The reservoir of Plasmodium infection in humans has traditionally been defined by blood slide positivity. This study was designed to characterize the local reservoir of infection in relation to the diverse var genes that encode the major surface antigen of Plasmodium falciparum blood stages and underlie the parasite's ability to establish chronic infection and transmit from human to ...

A four-dimensional ensemble variational (4D-EnVar) data assimilation has been developed for a limited area model. The integration of tangent linear and adjoint models, as applied in standard 4D-Var, is replaced with the use of an ensemble of non-linear model states to estimate fourdimensional background error covariances over the assimilation time window. The computational costs for 4D-En-Var a...