BACKGROUND Limited data are available on efficacy, safety, and long-term prognosis after cardiac resynchronization therapy (CRT) in elderly patients. We aimed at evaluating the effect of CRT, device-related adverse events, and long-term outcome after CRT among elderly patients. METHODS AND RESULTS A total of 798 CRT recipients (208 elderly: age, ≥75 years; 590 nonelderly: age, <75 years) unde...

Purpose To investigate the association of clinical outcomes with platelet function-guided modification in antiplatelet therapy in patients with ischemic stroke. Results Among 812 patients, 223 patients had aspirin nonresponse, 204 patients was modified in antiplatelet therapy after platelet function testing. Mean follow-up period was 4.8 ± 1.7 years (ranged from 1 to 6.4 years). The incidence...

We proposed an illness-death model with Lin and Ying's additive hazard and additive frailty for the regression analysis on semi-competing risks problem in a general morbidity/mortality process. Comparing with the Cox-type hazard, the additive hazard function is more natural and properly partitions the effect of the covariate on one transition into the other transition, internal consistency in t...

OBJECTIVE Depression may be associated with increased mortality risk, but there are substantial limitations to existing studies assessing this relationship. We sought to overcome limitations of existing studies by conducting a large, national, longitudinal study to assess the impact of depression on all-cause and cause-specific risk of death. METHODS We used Cox regression models to estimate ...

in this paper, the cox proportional hazard model is used to answer several questions. in general, fourteen variables are applied in four groups: firm, industry, expenditure human resources specific characteristics as well. according to the previous literature in this field, the findings of this paper also show that the factors which affect life duration of firms are different between industries...

2017 Background: We assessed the longitudinal hazard characteristics for death and progression in newly diagnosed GBM patients, evaluated the impact of prognostic factors and treatment on the hazard within different time intervals to determine if effects are time-variant, and quantified the prognostic influence of disease progression on survival. METHODS Among patients randomized to Radiation...

This paper explores implications of nominal rigidity characterized by a non-constant hazard function for aggregate dynamics. I derive the NKPC under an arbitrary hazard function and parameterize it with the Weibull duration model. The resulting Phillips curve involves lagged in‡ation and lagged expectations. It nests the Calvo NKPC as a limiting case in the sense that the e¤ects of both terms a...

investigation of reliability characteristics under fuzzy environments is proposed in this paper. fuzzy weibull distribution and lifetimes of components are using it described. formulas of a fuzzy reliability function, fuzzy hazard function and their α-cut set are presented. furthermore, the fuzzy functions of series systems and parallel systems are discussed, respectively. finally, some numeric...

BACKGROUND Left ventricular (LV) mass ascertained using echocardiography may enhance risk stratification for sudden cardiac death. The objective of this study was to assess the association between left ventricular mass and the risk of sudden cardiac death in a population-based cohort and determine its incremental value beyond conventional risk predictors. METHODS AND RESULTS Assessment of LV ...

BACKGROUND Left ventricular function is a principal determinant of cardiovascular risk in patients with heart failure. The growing number of patients with preserved systolic function heart failure underscores the importance of understanding the relationship between ejection fraction and risk. METHODS AND RESULTS We studied 7599 patients with a broad spectrum of symptomatic heart failure enrol...