Abstract Objectives: Essential tremor (ET) is a disabling condition resulting from cerebello-thalamo-cortical circuitry dysfunction. Deep brain stimulation of the thalamic ventral intermediate nucleus (VIM-DBS) effective in managing severe postural and action tremor. Non-invasive electrical cerebellum has recently emerged as potential therapeutic option for these patients. In this study, we aim...

Introduction Deep brain stimulation (DBS) is an established surgical treatment for Parkinson’s disease (PD), essential tremor and dystonia. It is generally acknowledged that the development of DBS as we know it today started with the publication of Benabid, Pollak et al in 1987 on thalamic DBS for tremor. However stereotactic surgery for PD was very common in the pre-levodopa era, and the vast ...

BACKGROUND Deep brain stimulation (DBS) for essential tremor (ET) can cause unwanted side effects. CASE REPORT A patient with ET underwent unilateral dual-lead thalamic DBS. He later developed parkinsonism with atypical features and was diagnosed with progressive supranuclear palsy. During presentation for a second opinion, stimulation-induced side effects were suspected. Inactivation of DBS ...

Herrington TM, Cheng JJ, Eskandar EN. Mechanisms of deep brain stimulation. J Neurophysiol 115: 19–38, 2016. First published October 28, 2015; doi:10.1152/jn.00281.2015.—Deep brain stimulation (DBS) is widely used for the treatment of movement disorders including Parkinson’s disease, essential tremor, and dystonia and, to a lesser extent, certain treatment-resistant neuropsychiatric disorders i...

Deep brain stimulation (DBS) may be considered in severe cases of therapy-refractory major depressive disorder (MDD). However, DBS for MDD is still an experimental therapy. Therefore, it should only be administered in clinical studies driven by multidisciplinary teams, including surgeons with substantial experience of DBS in the treatment of other conditions.

Deep brain stimulation (DBS) for Parkinson's disease is an effective treatment however challenges remain in accurate targeting of the deep brain structures. Existing indirect DBS targeting relies on registration of 2D histological atlases [1] since many deep brain structures are not clearly visible in traditional images. Gradient echo images obtained with ultra-high-field 7 Tesla MRI can reveal...

Continuous high-frequency deep brain stimulation (DBS) is a widely used therapy for advanced Parkinson's disease (PD) management. However, the mechanisms underlying DBS effects remain enigmatic and are the subject of an ongoing debate. Here, we present and test a closed-loop stimulation strategy for PD in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) primate model of PD. Application o...

We report on the pathological findings in the brains of 8 Parkinson's disease patients treated with deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus (6 cases) and subthalamic nucleus (2 cases). DBS was performed continuously for up to 70 months. All brains showed well-preserved neural parenchyma and only mild gliosis around the lead track compatible with reactive change...

The use of deep brain stimulation (DBS) to control severely disabling neurological and psychiatric conditions is an exciting and fast emerging area of neuroscience. Deep brain stimulation has generally the same clinical effects as a lesion with respect to the improvement of clinical disability, but has more advantages such as its adjustability and reversibility. To this day, fundamental knowled...

Deep brain stimulation (DBS) has become a well-accepted therapy to treat movement disorders, including Parkinson's disease, essential tremor, and dystonia. Long-term follow-up studies have demonstrated sustained improvement in motor symptoms and quality of life. DBS offers the opportunity to selectively modulate the targeted brain regions and related networks. Moreover, stimulation can be adjus...