Given the deformation and instability of layered floor weakly cemented soft rock roadway, taking mining roadway Meihuajing Mine as engineering background, mechanism control measures surrounding under different stratum combination conditions are studied by using methods field investigation, numerical calculation test. The results show that: (1) characteristics in roadways significant, structure ...

The optic tectum of larval zebrafish is an important model for understanding visual processing in vertebrates. The tectum has been traditionally viewed as dominantly visual, with a majority of studies focusing on the processes by which tectal circuits receive and process retinally-derived visual information. Recently, a handful of studies have shown a much more complex role for the optic tectum...

Griseofulvin, an orally effective antimicrobial agent, appears in the stratum corneum within 4-8 h after oral administration. Griseofulvin distribution was found to be highest in the outermost layers of the stratum corneum (level I, 20.8+/-1.5 ng/mg) and lowest inside (level II, 10.0+/-1.5; level III, 7.5+/-2.2 ng/mg). In order to study the precise mechanism of griseofulvin transfer to stratum ...

As a new category of therapeutics for skin diseases including atopic dermatitis (AD), nucleic acids are gaining importance in the clinical setting. Intradermal administration is noninvasive and improves patients' quality of life. However, intradermal small interfering RNA (siRNA) delivery is difficult because of two barriers encountered in the skin: intercellular lipids in the stratum corneum a...

More than 30 years of continuous development has made onshore deep and ultra-deep conventional unconventional oil gas become an integral part increasing the energy reserves output by China’s petroleum industry. Based on geological conditions in country, present study finds that paleo stratum burial are two basic characteristics gas. Furthermore, we put forward notion it is necessary to strengthe...

An atomic force microscope (AFM) and a tunable infrared (IR) laser source have been combined in a single instrument (AFM-IR) capable of producing ~200-nm spatial resolution IR spectra and absorption images. This new capability enables IR spectroscopic characterization of human stratum corneum at unprecendented levels. Samples of normal and delipidized stratum corneum were embedded, cross-sectio...

Ever since Ervin Blank discovered1 the importance of moisturizing the stratum corneum, companies have focused their attention on developing a better surface barrier or improving skin surface moisturization in the outer layers of the stratum corneum. More recently, agents such as peroxisomal proliferator-activated receptor (PPAR) ligands have been developed and exploited in moisturizers. These a...

The stratum corneum dehydrates after exogenous hydration due to skincare or bathing. In this study, sheets of stratum corneum were isolated from reconstructed human epidermis and the barrier function and structure of these sheets were assessed during drying with the aim of improving our understanding of skincare. Water diffusion through the sheets of stratum corneum decreased with drying, accom...

The outermost layer of the human skin, the stratum corneum (SC), is comprised of structurally inter-positioned anatomical regions. This inter-positioning renders the electrical characterization of its individual region difficult. To address this difficulty, the SC’s electrical properties at the cellular level were investigated. Impedance measurements were performed using a planar microelectrode...