introduction: stroke is one of the most important reasons of death. hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide. the ischemia-reperfusion causes hypoxia, hypoglycemia and incomplete repel of metabolic waste products and leads to accumulation of free radicals triggering neuronal death. the a1 adenosine receptoras an endogenous l...

Background Tau plays a critical role in neurodegeneration, thus targeting this protein to control its accumulation is important prevent or delay neurotoxicity tauopathies like Alzheimer’s disease (AD). Discrete molecular chaperones, Aha1 and FKBP52, are known affect the stability of tau by promoting phosphorylation, aggregation and, some mouse models, neuronal death. However, one limitation pre...

The effect of seizures on neuronal death and the role of seizure-induced neuronal death in acquired epileptogenesis have been debated for decades. Isolated brief seizures probably do not kill neurons; however, severe and repetitive seizures (i.e., status epilepticus) certainly do. Because status epilepticus both kills neurons and also leads to chronic epilepsy, neuronal death has been proposed ...

Alzheimer’s disease is one of the most prevalent neurodegenerative diseases in world which mostly appears with aging [1,2]. Neuronal death, followed by cognitive decline and memory loss serve as an important outcome [3].

PURPOSE To study the impact of the mitochondrial ubiquitin ligase MARCH5 on mitochondrial morphology and induction of apoptosis using an in vitro model of neuronal precursor cells exposed to glaucoma-relevant stress conditions. METHODS RGC5 cells transfected with expression constructs for MARCH5, MARCH5(H43W), Dpr1(K38A) or vector control were exposed to either elevated pressure of 30 mmHg, o...

The existing activation functions ReLU, Tanh, and Mish have problems such as "neuronal death", offset, poor robustness. Aiming at these problems, the XExp function is proposed by combining advantages of Swish, functions, problem negative half-axis neuronal death optimized using nonlinearity non-RELU family non-zero characteristics soft saturation semi-axis retained. By designing position origin...

Anticipation of predictable events is crucial for organizing motor performance. Using instructed delay tasks, it has been shown that even when delay duration is kept constant, reaction time fluctuates from trial to trial. As time estimation is at the core of anticipatory behavior, it is reasonable to speculate whether neuronal delay activity correlates with the subjective estimate of time. As a...